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2017 | 64 | 4 | 713-718
Article title

Nano-emulsions as vehicles for topical delivery of forskolin

Content
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Languages of publication
EN
Abstracts
EN
Two O/W forskolin-loaded nano-emulsions (0.075% wt.) based on medium chain triglycerides (MCT) and stabilized by a nonionic surfactant (Polysorbate 80 or Polysorbate 40) were studied as forskolin delivery systems. The nano-emulsions were prepared by the PIC method. The mean droplet size of the nano-emulsions with Polysorbate 80 and Polysorbate 40 with oil/surfactant (O/S) ratios of 20/80 and 80% water concentration, measured by Dynamic Light Scattering (DLS), was of 118 nm and 111 nm, respectively. Stability of the formulations, as assessed by light backscattering for 24 h, showed that both nano-emulsions were stable at 25°C. Studies of forskolin in vitro skin permeation from the nano-emulsions and from a triglyceride solution were carried out at 32°C, using Franz-type diffusion cells. A mixture of PBS/ethanol (60/40 v/v) was used as a receptor solution. The highest flux and permeability coefficient was obtained for the system stabilized with Polysorbate 80 (6.91±0.75 µg · cm-2·h-1 and 9.21 · 10-3±1.00 · 10-3 cm · h-1, respectively) but no significant differences were observed with the flux and permeability coefficient value of forskolin dissolved in oil. The obtained results showed that the nano-emulsions developed in this study could be used as effective carriers for topical administration of forskolin.
Publisher

Year
Volume
64
Issue
4
Pages
713-718
Physical description
Dates
published
2017
received
2017-10-05
revised
2017-11-13
accepted
2017-11-19
(unknown)
2017-12-13
Contributors
  • Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland
  • Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland
author
  • Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland
  • Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain, IN2UB members
  • Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain, IN2UB members
  • Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain
  • Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv64p713kz
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