Physicochemical properties and cytotoxicity of hydrogels based on Beetosan® containing sage and bee pollen

• Authors: Bożena Tyliszczak , Anna Drabczyk , Sonia Kudłacik-Kramarczyk , Beata Grabowska , Magdalena Kędzierska
• Languages of publication: EN

Abstracts

EN

Currently, increasing attention is being paid to issues related to environmental protection, waste management, as well as to the development of polymers with useful properties. The research presented here involved preparation of hydrogels based on Beetosan® - a chitosan derived from the multi-stage processing of dead bees. Moreover, hydrogels were additionally modified with natural substances - i.e. bee pollen and extract of Salvia officinalis (sage) that are well known for the presence of many compounds with beneficial properties from a medical point of view. Materials have been first obtained by photopolymerization. Then, their surface morphology, wettability and cytotoxicity to selected cell lines have been determined. It can be stated that such combination of Beetosan® hydrogel matrix and the mentioned additives resulted in a preparation of polymers characterized by negative impact on cancer cells. Impact of hydrogels with sage is slightly more intense due to the presence of substances such as ursalic or rosmaric acid that are characterized to have anticancer activity. Such negative impact has not been observed in case of studies using fibroblasts. Furthermore, addition of natural substances into hydrogels resulted in a more homogeneous surface and in the decrease of wettability angle of the tested polymers. It can be concluded that the use of natural-derived reagents and synthesis of polymers using these reagents (as a result of environmentally friendly photopolymerization) yields materials with interesting properties for medical purposes, with particular emphasis on antitumor activity, and without significant negative impact on fibroblasts.

Keywords

EN

hydrogels; cytotoxicity; fibroblasts; chitosan; sage; wettability

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 4
• Pages: 709-712

Dates

published

2017

received

2017-09-15

revised

2017-11-13

accepted

2017-11-22

(unknown)

2017-12-10

Contributors

author

Bożena Tyliszczak

• Department of Chemistry and Technology of Polymers, Cracow University of Technology, Kraków, Poland

author

Anna Drabczyk

• Institute of Inorganic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Sonia Kudłacik-Kramarczyk

• Institute of Inorganic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Beata Grabowska

• Faculty of Foundry Engineering, AGH University of Science and Technology in Kraków, Kraków, Poland

author

Magdalena Kędzierska

• Medical University of Lodz, Łódź, Poland

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Identifiers

DOI

10.18388/abp.2017_2319