The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115

• Authors: Andrzej Łazarenkow , Marta Michalska , Marek Mirowski , Krzysztof Słomiak , Jolanta Nawrot-Modranka
• Languages of publication: EN

Abstracts

EN

The hydrazine derivatives of benzopyrones remain an unexplored group of chemical compounds. This preliminary study investigates the influence of A-5, CH-3 and K-2 derivatives at concentrations of 1, 10, 100 nM and 1 μM on selected biochemical factors of a melanoma cell line WM-115, with regard to their potential angiogenic properties. The studied compounds were found to influence cell proliferation, as well as total protein, bFGF and FGFR1 concentration.

Keywords

EN

angiogenesis; basic fibroblast growth factor; fibroblast growth factor receptor 1; human melanoma; hydrazone derivatives of benzo-γ-pyrones

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 3
• Pages: 585-590

Dates

published

2017

received

2017-03-14

revised

2017-07-11

accepted

2017-07-14

(unknown)

2017-09-07

Contributors

author

Andrzej Łazarenkow

• Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

author

Marta Michalska

• Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Interdepartmental Chair of Laboratory and Molecular Diagnostics, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

author

Marek Mirowski

• Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Interdepartmental Chair of Laboratory and Molecular Diagnostics, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

author

Krzysztof Słomiak

• Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

author

Jolanta Nawrot-Modranka

• Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

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Identifiers

DOI

10.18388/abp.2017_1565