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2017 | 64 | 3 | 585-590
Article title

The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115

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The hydrazine derivatives of benzopyrones remain an unexplored group of chemical compounds. This preliminary study investigates the influence of A-5, CH-3 and K-2 derivatives at concentrations of 1, 10, 100 nM and 1 μM on selected biochemical factors of a melanoma cell line WM-115, with regard to their potential angiogenic properties. The studied compounds were found to influence cell proliferation, as well as total protein, bFGF and FGFR1 concentration.
Physical description
  • Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
  • Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Interdepartmental Chair of Laboratory and Molecular Diagnostics, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
  • Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Interdepartmental Chair of Laboratory and Molecular Diagnostics, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
  • Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
  • Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
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