Short-term proton pump inhibitor treatment may cause hypomagnesaemia in critically ill patients - a pilot study

• Authors: Łukasz Krzych , Piotr Łój , Teresa Nowak , Wojciech Kazura , Piotr Knapik
• Languages of publication: EN

Abstracts

EN

Many studies have suggested a link between long-term PPI treatment and hypomagnesaemia, though none of them investigated the short-term exposure in high-risk patients. We sought to investigate this issue in 90 critically ill patients. We assessed serum Mg concentrations, necessity of Mg supplementation, PPI dose, duration of PPI therapy and route of administration. In multiple analysis we found that Mg supplementation (positive effect/p=0.03) and enteral route of PPI administration (negative effect/p=0.02) had significant impact on Mg concentration. Although the deleterious relationship between short-term PPI treatment and Mg concentration was found, further studies should be provided to confirm this interesting effect.

Keywords

EN

proton-pump inhibitors; hypomagnesaemia; critically ill

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 3
• Pages: 499-501

Dates

published

2017

received

2017-01-12

revised

2017-02-28

accepted

2017-04-04

(unknown)

2017-06-24

Contributors

author

Łukasz Krzych

• Department of Anaesthesiology and Intensive Care, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

author

Piotr Łój

• Department of Anaesthesiology and Intensive Care, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

author

Teresa Nowak

• Students' Scientific Society, Department of Anaesthesiology and Intensive Care, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

author

Wojciech Kazura

• Students' Scientific Society, Department of Anaesthesiology and Intensive Care, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

author

Piotr Knapik

• Department of Cardiac Anaesthesia and Intensive Therapy, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland

References

• Bai JP, Hausman E, Lionberger R, Zhang X (2012) Modeling and simulation of the effect of proton pump inhibitors on magnesium homeostasis. 1. Oral absorption of magnesium. Mol Pharm 9: 3495--505.
• Danziger J, William JH, Scott DJ, Lee J, Lehman LW, Mark RG, Howell MD, Celi LA, Mukamal KJ (2013) Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int 83: 692-699. doi: 10.1038/ki.2012.452.
• El-Charabaty E, Saifan C, Abdallah M, Naboush A, Glass D, Azzi G, Azzi Y, Khan A, Baydoun H, Rondla C, Parekh N, El-Sayegh S (2013) Effects of proton pump inhibitors and electrolyte disturbances on arrhythmias. Int J Gen Med 6: 515-518. doi: 10.2147/IJGM.S46932.
• Epstein M, McGrath S, Law F (2006) Proton-pump inhibitors and hypomagnesemic hypoparathyroidism. N Engl J Med 355: 1834-1836.
• Hoorn EJ, van der Hoek J, de Man RA, Kuipers EJ, Bolwerk C, Zietse R (2010) A case series of proton pump inhibitor-induced hypomagnesemia. Am J Kidney Dis 56: 112-116. doi: 10.1053/j.ajkd.2009.11.019.
• Kieboom BC, Kiefte-de Jong JC, Eijgelsheim M, Franco OH, Kuipers EJ, Hofman A, Zietse R, Stricker BH, Hoorn EJ (2015) Proton pump inhibitors and hypomagnesemia in the general population: a population-based cohort study. Am J Kidney Dis 66: 775-782. doi: 10.1053/j.ajkd.2015.05.012.
• Krag M, Perner A, Moller MH (2016) Stress ulcer prophylaxis in the intensive care unit. Curr Opin Crit Care 22: 186-190.
• Park CH, Kim EH, Roh YH, Kim HY, Lee SK (2014) The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis. PLoS One 9: e112558. doi: 10.1371/journal.pone.0112558.
• Toh JW, Ong E, Wilson R (2015) Hypomagnesaemia associated with long-term use of proton pump inhibitors. Gastroenterol Rep (Oxf) 3: 243-253.
• William JH, Danziger J (2016) Magnesium deficiency and proton-pump inhibitor use: a clinical review. J Clin Pharmacol 56: 660-668. doi: 10.1002/jcph.672.
• William JH, Danziger J (2016) Proton-pump inhibitor-induced hypomagnesemia: current research and proposed mechanisms. World J Nephrol 5: 152-157. doi: 10.5527/wjn.v5.i2.152.
• Zipursky J, Macdonald EM, Hollands S, Gomes T, Mamdani MM, Paterson JM, Lathia N, Juurlink DN (2014) Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case-control study. PLoS Med 11: e1001736. doi: 10.1371/journal.pmed.1001736.

Identifiers

DOI

10.18388/abp.2017_1505