Prognostic value of perioperative assessment of plasma cardiac troponin I in patients undergoing liver transplantation

• Authors: Krzysztof Jankowski , Janusz Trzebicki , Maksymilian Bielecki , Beata Łągiewska , Katarzyna Kurnicka , Magdalena Koczaj-Bremer , Marek Pacholczyk , Piotr Pruszczyk
• Languages of publication: EN

Abstracts

EN

Abstract. An elevation in plasma cardiac troponins is an indicator of increased perioperative risk in orthopaedic and vascular surgery, however, data on liver transplantation (LTx) are scarce. The aim of the study was to evaluate the prevalence of cardiac troponin I (cTnI) elevation in the perioperative period of LTx, and its potential relationship with 1-year mortality. Material and methods. Analysis included 79 patients with liver cirrhosis. During LTx all patients underwent hemodynamic measurements. cTnI level was determined before the operation, 24, 48 and 72 hours afterwards. One-year mortality was assessed. Results. 12.7% patients died, all during in-hospital period. cTnI level on day 1. was identified as the most promising marker of increased death risk with optimal cut-off value of 0.215 ng/mL (the sensitivity of 60.0%, specificity of 87.0%, positive predictive value of 40.0%, negative predictive value of 93.8%). The most important predictor of cTnI increase was the duration of the LTx procedure followed by amount of packed red blood cells transfused, basic stroke volume index, and cardiac output index. In conclusion: value of cTnI level assessed 24 hours post-surgery was a reliable predictor of death following LTx with optimal cut-off value of 0.215 ng/mL. The surgery time was the most important predictor of cTnI elevation.

Keywords

EN

cardiac troponin I; liver transplantation; surgery time

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 2
• Pages: 331-337

Dates

published

2017

received

2016-10-05

revised

2017-02-13

accepted

2017-02-25

(unknown)

2017-04-25

Contributors

author

Krzysztof Jankowski

• Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland

author

Janusz Trzebicki

• Department of Anaesthesiology and Intensive Care, Medical University of Warsaw, Warsaw, Poland

author

Maksymilian Bielecki

• Department of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland

author

Beata Łągiewska

• Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland

author

Katarzyna Kurnicka

• Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland

author

Magdalena Koczaj-Bremer

• Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland

author

Marek Pacholczyk

• Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland

author

Piotr Pruszczyk

• Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland

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Identifiers

DOI

10.18388/abp.2016_1436