Anticancer activity of some polyamine derivatives on human prostate and breast cancer cell lines

• Authors: Marta Szumilak , Malgorzata Galdyszynska , Kamila Dominska , Andrzej Stanczak , Agnieszka Piastowska-Ciesielska
• Languages of publication: EN

Abstracts

EN

The aim of this study was to expand our knowledge about anticancer activity of some polyamine derivatives with quinoline or chromane as terminal moieties. Tested compounds were evaluated in vitro towards metastatic human prostate adenocarcinoma (PC3), human carcinoma (DU145) and mammary gland adenocarcinoma (MCF7) cell lines. Cell viability was estimated on the basis of mitochondrial metabolic activity using water-soluble tetrazolium WST1 to establish effective concentrations of the tested compounds under experimental conditions. Cytotoxic potential of polyamine derivatives was determined by the measurement of lactate dehydrogenase activity released from damaged cells, changes in mitochondrial membrane potential, the cell cycle distribution analysis and apoptosis assay. It was revealed that the tested polyamine derivatives differed markedly in their antiproliferative activity. Bischromane derivative 5a exhibited a rather cytostatic than cytotoxic effect on the tested cells, whereas quinoline derivative 3a caused changes in cell membrane integrity, inhibited cell cycle progression, as well as induced apoptosis of prostate and breast cancer cells which suggest its potential application in cancer therapy.

Keywords

EN

polyamine derivatives; prostate cancer; breast cancer; mitochondrial potential; cell cycle; apoptosis

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 2
• Pages: 307-313

Dates

published

2017

received

2016-08-24

revised

2016-12-21

accepted

2016-12-28

(unknown)

2017-04-14

Contributors

author

Marta Szumilak

• Department of Hospital Pharmacy, Faculty of Pharmacy, Medical University of Lodz, Łódź, Poland

author

Malgorzata Galdyszynska

• Department of Comparative Endocrinology, Medical University of Lodz, Łódź, Poland

author

Kamila Dominska

• Department of Comparative Endocrinology, Medical University of Lodz, Łódź, Poland

author

Andrzej Stanczak

• Department of Hospital Pharmacy, Faculty of Pharmacy, Medical University of Lodz, Łódź, Poland

author

Agnieszka Piastowska-Ciesielska

• Department of Comparative Endocrinology, Medical University of Lodz, Łódź, Poland
• Laboratory of Cell Cultures and Genomic Analysis, Medical University of Lodz, Łódź, Poland

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Identifiers

DOI

10.18388/abp.2016_1416