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2017 | 64 | 2 | 233-238
Article title

Age-dependent systemic DNA damage in early Type 2 Diabetes mellitus

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EN
Abstracts
EN
Oxidative stress, capable of eliciting damage to various biomolecules including DNA, is a recognized component of diabetes mellitus and its complications. Metabolic syndrome (MetS) is associated with the development of type 2 diabetes mellitus (T2DM), as well as other unfavorable outcomes. The aim of this study was to elucidate the role of oxidative stress in the development of T2DM, by investigating association of oxidative DNA damage with metabolic parameters in subjects with MetS and early T2DM. Selected anthropometric and biochemical parameters of MetS, inflammation and oxidative DNA damage: body mass index (BMI), fatty liver index (FLI), waist circumference (WC), total cholesterol, HDL and LDL-cholesterol, gamma-glutamyl transpeptidase (GGT), uric acid, C-reactive protein (CRP), total leukocyte/neutrophil count, and urinary 8-hidroxy-deoxyguanosine (u-8-OHdG) were assessed in male subjects with MetS and both younger (≤55 years) and older (>55 years) subjects with T2DM of short duration without complications. BMI, FLI, WC, total and LDL-cholesterol and uric acid were higher, while the u-8-OHdG was lower in MetS group, when compared to older T2DM subjects. None of these parameters were different neither between MetS and younger T2DM, nor between two sub-groups of subjects with T2DM. Values of CRP, HDL-cholesterol, triglycerides, GGT, leukocytes and neutrophils were not different between all examined groups of subjects. Higher 8-OHdG in older subjects with T2DM suggests that both aging process and diabetes could contribute to the development of DNA damage. Oxidative DNA damage cannot serve as an universal early marker of T2DM.
Publisher

Year
Volume
64
Issue
2
Pages
233-238
Physical description
Dates
published
2017
received
2016-05-05
revised
2016-07-12
accepted
2016-10-06
(unknown)
2017-03-30
Contributors
author
  • Department of Internal Medicine, General Hospital Brežice, Slovenia
  • General Hospital Varaždin, Department for extending and palliative care Novi Marof, Croatia
  • NMR Centre, Institute Rudjer Bošković, Zagreb, Croatia
  • Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, University Hospital Merkur, Zagreb, Croatia
  • Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, University Hospital Merkur, Zagreb, Croatia
author
  • Polyclinic Sunce, Zagreb, Croatia
  • Polyclinic Sunce, Zagreb, Croatia
author
  • Department of Internal Medicine, University Hospital Centre Split, Split, Croatia
  • Department of Internal Medicine, University Hospital Sveti Duh, Zagreb, Croatia
  • Department of Laboratory Medicine, Scientific Research Unit, University Hospital Merkur, Zagreb, Croatia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv64p233kz
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