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2017 | 64 | 1 | 183-187
Article title

Mitochondrial DNA in pediatric leukemia patients

Content
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EN
Abstracts
EN
Numerous studies of mitochondrial DNA (mtDNA) in cancer have shown differences between mtDNA sequences in tumor and normal tissue and at various stages of cancer treatment in the same patient. However, there is little data on acute lymphoblastic leukemia (ALL), the most common type of leukemia in children. In this study we compared mitochondrial sequence variation in the D-loop region and in 5 genes of mtDNA in bone marrow samples of 6 pediatric patients with ALL at various stages of therapy. We found several common polymorphisms and one variant at position 3688 whose level varied during leukemia treatment. Our results suggest that mitochondrial DNA mutations, whose levels change during patient treatment, could be potential biomarkers for monitoring treatment efficacy and disease progression.
Keywords
Year
Volume
64
Issue
1
Pages
183-187
Physical description
Dates
published
2017
received
2016-10-20
revised
2016-11-11
accepted
2016-12-06
(unknown)
2017-03-09
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv64p183kz
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