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2016 | 63 | 4 | 825-833
Article title

Retroposition as a source of antisense long non-coding RNAs with possible regulatory functions

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Abstracts
EN
Long non-coding RNAs (lncRNAs) are a class of intensely studied, yet enigmatic molecules that make up a substantial portion of the human transcriptome. In this work, we link the origins and functions of some lncRNAs to retroposition, a process resulting in the creation of intronless copies (retrocopies) of the so-called parental genes. We found 35 human retrocopies transcribed in antisense and giving rise to 58 lncRNA transcripts. These lncRNAs share sequence similarity with the corresponding parental genes but in the sense/antisense orientation, meaning they have the potential to interact with each other and to form RNA:RNA duplexes. We took a closer look at these duplexes and found that 10 of the lncRNAs might regulate parental gene expression and processing at the pre-mRNA and mRNA levels. Further analysis of the co-expression and expression correlation provided support for the existence of functional coupling between lncRNAs and their mate parental gene transcripts.
Publisher

Year
Volume
63
Issue
4
Pages
825-833
Physical description
Dates
published
2016
received
2016-06-04
revised
2016-06-30
accepted
2016-07-19
(unknown)
2016-11-02
Contributors
  • Department of Integrative Genomics, Institute of Antropology, Adam Mickiewicz University in Poznan, Poznań, Poland
  • Department of Integrative Genomics, Institute of Antropology, Adam Mickiewicz University in Poznan, Poznań, Poland
  • Department of Integrative Genomics, Institute of Antropology, Adam Mickiewicz University in Poznan, Poznań, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv63p825kz
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