RNA dactyloscopy

• Authors: Marta Gabryelska , Eliza Wyszko , Jan Barciszewski
• Languages of publication: EN

Abstracts

EN

Despite the wealth of data on RNA secondary structure, conformational dynamics and tertiary structure in vitro and in vivo, predicting RNA biological activity in cellular environments remains difficult. Here, we present a comparison between in silico RNA fingerprinting and published experimental data that sheds light on efficient design of the hammerhead ribozyme molecules with a high intracellular efficiency. Our method, which we call RNA dactyloscopy, is a reliable tool for assessing the catalytic properties, modeling and design of RNA.

Keywords

EN

hammerhead ribozyme; RNA tertiary structure; fingerprint

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 4
• Pages: 785-787

Dates

published

2016

received

2016-05-31

revised

2016-06-21

accepted

2016-08-05

(unknown)

2016-12-01

Contributors

author

Marta Gabryelska

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland
• Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

author

Eliza Wyszko

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland

author

Jan Barciszewski

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland

References

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Identifiers

DOI

10.18388/abp.2016_1341