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2016 | 63 | 4 | 725-729
Article title

Circulating microRNAs in Cardiovascular Diseases

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EN
Abstracts
EN
Cardiovascular Diseases (CD) are currently one of the most common causes of death. Because heart related deaths occur on such an enormous scale this phenomenon is referred to as an epidemic. Chronic and acute injury of the heart could be an effect of cardiac remodeling, which is a result of molecular, cellular and interstitial changes, influenced by hemodynamic load or neurohormonal activation (Cohn et al., 2000). These small deviations in cardiac activity and morphology may lead to an enormous negative effect. Despite a significant progress, knowledge of standard risk factors for cardiovascular diseases has become less and less effective, which is why predicting and seeking an appropriate treatment is very challenging. As a result, there is a growing interest in finding new markers of the CD. MicroRNAs (miRNAs), are short, non-coding RNAs responsible for regulation of gene expression at the post-transcriptional level. Among them that have the greatest potential are microRNA molecules that circulate in the blood plasma or serum, that are related to direct activation of signaling pathways, implicated in the aging process and thus for the development of cardiovascular disease. This paper is a summary of the current state of knowledge on miRNAs, their biogenesis and potential role as biomarkers to diagnose heart disease.
Publisher

Year
Volume
63
Issue
4
Pages
725-729
Physical description
Dates
published
2016
received
2016-05-30
revised
2016-06-23
accepted
2016-07-05
(unknown)
2016-10-19
Contributors
  • Laboratory of Subcellular Structures Analyses, Department of Epigenetics, Institute of Bioorganic Chemistry Polish Academy of Sciences, Poznań, Poland
author
  • Laboratory of Subcellular Structures Analyses, Department of Epigenetics, Institute of Bioorganic Chemistry Polish Academy of Sciences, Poznań, Poland
  • Laboratory of Subcellular Structures Analyses, Department of Epigenetics, Institute of Bioorganic Chemistry Polish Academy of Sciences, Poznań, Poland
  • Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznań, Poland
author
  • Laboratory of Subcellular Structures Analyses, Department of Epigenetics, Institute of Bioorganic Chemistry Polish Academy of Sciences, Poznań, Poland
References
  • Adachi T, Nakanishi M, Otsuka Y, Nishimura K, Hirokawa G, Goto Y, Nonogi H, Iwai N (2010) Plasma MicroRNA 499 as a biomarker of acute myocardial infarction. Clin Chem 56: 1183-1185. https://doi.org/10.1373/clinchem.2010.144121.
  • Arroyo J, Chevillet J, Kroh E, Ruf I, Pritchard C, Gibson D, Mitchell P, Bennett C, Pogosova-Agadjanyan E, Stirewalt D, Tait J, Tewari M (2011) Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 108: 5003-5008.
  • Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297. doi: doi: 10.1016/S0092-8674(04)00045-5.
  • Boon RA, Dimmeler S (2015) MicroRNAs in myocardial infarction. Nat Rev Cardiol 12: 135-142. https://doi.org/10.1038/nrcardio.2014.207.
  • Borchert GM, Lanier W, Davidson BL (2006) RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol 13: 1097-1101. https://doi.org/10.1038/nsmb1167.
  • Bostjancic E, Zidar N, Stajer D, Glavac D (2010) MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction. Cardiology 115: 163-169. https://doi.org/10.1159/000268088.
  • Bronze-da-Rocha E (2014) MicroRNAs expression profiles in cardiovascular diseases. Biomed Res Int 2014: 985408. https://doi.org/10.1155/2014/985408.
  • Callis TE, Pandya K, Seok HY (2009) MicroRNA-208a is a regulator of hypertrophy and conduction in mice. J Clin Invest 119: 2772-2786. https://doi.org/10.1172/JCI36154.
  • Cohn J, Ferrari R, Sharpe N (2000) Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. J Am Coll Cardiol 35: 569-582.
  • Condorelli G, Latronico MV, Cavarretta E (2014) microRNAs in cardiovascular diseases. J Am Coll Cardiol 63: 2177-2187. https://doi.org/10.1016/j.jacc.2014.01.050.
  • Corsten MF, Dennert R, Jochems S, Kuznetsova T, Devaux Y, Hofstra L, Wagner DR, Staessen JA, Heymans S, Schroen B (2010) Circulating microrna-208b and microrna-499 reflect myocardial damage in Cardiovascular Disease. Circ Cardiovasc Genet 3: 499-506. https://doi.org/10.1161/CIRCGENETICS.110.957415.
  • D'Alessandra Y, Devanna P, Limana F, Straino S, Di Carlo A, Brambilla PG, Rubino M, Carena MC, Spazzafumo L, De Simone M, Micheli B, Biglioli P, Achilli F, Martelli F, Maggiolini S, Marenzi G, Pompilio G, Capogrossi MC (2010) Circulating micrornas are new and sensitive biomarkers of myocardial infarction. Eur Heart J 31: 2765-2773. https://doi.org/10.1093/eurheartj/ehq167.
  • Fic P, Kowalczuk K, Grabarska A, Stepulak A (2014) MicroRNAs - new diagnostic chances in Ischemic Heart Disease and Acute Myocardial Infarction. Postepy Hig Med Dosw (Online) 68: 410-418 (in Polish).
  • Fichtlscherer S, De Rosa S, Fox H, Schwietz T, Fischer A, Liebetrau C, Weber M, Hamm CW, Roxe T, Muller-Ardogan M, Bonauer A, Zeiher AM, Dimmeler S (2010) Circulating microRNAs in patients with coronary artery disease. Circ Res 107: 677-684. https://doi.org/10.1161/CIRCRESAHA.109.215566.
  • Gan CS, Wang CW, Tan KS (2012) Circulatory microRNA-145 expression is increased in cerebral ischemia. Genet Mol Res 11: 147-152. https://doi.org/10.4238/2012.January.27.1.
  • Grenda A, Budzyński M, Filip AA (2013) Biogenesis of microRNAs and its meaning in etiology and process of chosen haematological disorders. Postepy Hig Med Dosw (Online) 67: 174-185 (in Polish).
  • Gupta KS, Bang C, Thum T (2010) Circulating MicroRNAs as biomarkers and potential paracrine mediators of Cardiovascular Disease. Circ Cardiovasc Genet 3: 484-488. https://doi.org/10.1161/CIRCGENETICS.110.958363.
  • Hrustincova A, Votavova H, Dostalova Merkerova M (2015) Circulating microRNAs: methodological aspects in detection of these biomarkers. Folia Biologica 61: 203-218.
  • Isik M, Korswagen HC, Berezikov E (2010) Expression patterns of intronic microRNAs in Caenorhabditis elegans. Silence 1: 5 https://doi.org/10.1186/1758-907X-1-5.
  • Kaudewitz D, Zampetaki A, Mayr M (2015) MicroRNA biomarkers for coronary artery disease. Curr Atheroscler Rep 17: 70. https://doi.org/10.1007/s11883-015-0548-z.
  • Landgraf P, Rusu M, Sheridan R (2007) A mammalian microRNA expression atlas based on small library sequencing. Cell 129: 1401-1414.
  • Laterza OF, Lim L, Garrett-Engele PE (2009) Plasma microRNAs as sensitive and specific biomarkers of tissue injury. Clin Chem 55: 1977-1983.
  • Liao XB, Perez VA, Król M, Yeh CH, Yuan LQ (2015) MicroRNA and cardiovascular disease. Biomed Res Int 2015: 734380. https://doi.org/10.1155/2015/734380.
  • Meder B, Keller A, Vogel B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Just S, Borries A, Rudloff J, Leidinger P, Meese E, Katus HA, Rottbauer W (2011) Microrna signatures in total peripheral blood as novel biomarkers for acute myocardial infarction. Basic Res Cardiol 106: 13-23. https://doi.org/10.1007/s00395-010-0123-2.
  • Min PK, Chan SY (2015) The biology of circulating microRNA in cardiovascular disease. Eur J Clin Invest 45: 860-874. https://doi.org/10.1111/eci.12475.
  • Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105: 10513-10518. https://doi.org/10.1073/pnas.0804549105.
  • Mitchelson KR, Qin WY (2015) Roles of the canonical myomiRs miR-1, miR-133 and miR-206 in cell development and disease. World J Biol Chem 6: 162-208.
  • Ohshima K, Inoue K, Fujiwara A, Hatakeyama K, Kanto K, Watanabe Y, Muramatsu K, Fukuda Y, Ogura S, Yamaguchi K, Mochizuki T (2010) Let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. PLoS One 5: e13247. https://doi.org/10.1371/journal.pone.0013247.
  • Okamura K, Liu N, Lai EC (2009) Distinct mechanisms for microRNA strand selection by Drosophila argonautes. Mol Cell 36: 431-444. https://doi.org/10.1016/j.molcel.2009.09.027.
  • Pfeifer P, Werner N, Jansen N (2015) Role and function of MicroRNAs in extracellular vesicles in cardiovascular biology. Biomed Res Int 2015: 161393. https://doi.org/10.1155/2015/161393.
  • Romaine S, Tomaszewski M, Condorelli G, Samani N (2015) MicroRNAs in Cardiovascular Disease: an introduction for clinicians. Heart 101: 921-928. https://doi.org/10.1136/heartjnl-2013-305402.
  • Schulte C, Molz S, Appelbaum S, Karakas M, Ojeda F, Lau D, Hartmann T, Lackner KJ, Westermann D, Schnabel RB, Blankenberg S, Zeller T (2015) miRNA-197 and miRNA-223 predict cardiovascular death in a cohort of patients with symptomatic coronary artery disease. PLos One 10: e0145930. https://doi.org/10.1371/journal.pone.0145930.
  • Schulte C, Zeller T (2015) microRNA-based diagnostics and therapy in Cardiovascular Disease - Summing up the facts. Cardiovasc Diagn Ther 5: 17-36. https://doi.org/10.3978/j.issn.2223-3652.2014.12.03.
  • Shiyong Y, Guohong L (2010) MicroRNA expression and function in cardiac ischemic injury. J Cardiovasc Transl Res 3: 241-245.
  • Su Z, Yang Z, Xu Y, Chen Y, Yu Q (2015) MicroRNAs in apoptosis, autophagy and necroptosis. Oncotarget 6: 8474-8490.
  • Sun X, Zhang M, Sanagawa A, Mori C, Ito S, Iwaki S, Satoh H, Fujii S (2012) Circulating microRNA-126 in patients with coronary artery disease: correlation with LDL cholesterol. Thromb J 10: 16. https://doi.org/10.1186/1477-9560-10-16.
  • Thum T, Gross C, Fiedler J (2008) MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signaling in fibroblasts. Nature 456: 980-984.
  • Urbich C, Kuehbacher A, Dimmeler S (2008) Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res 79: 581-588. https://doi.org/10.1093/cvr/cvn156.
  • Van Empel V, De Windt L (2012) Circulating miRNAs: reflecting or affecting Cardiovascular Disease? Curr Hypertens Rep 14: 498-509.
  • van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN (2007) Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316: 575-579.
  • Vickers K, Palmisano B, Shoucri B, Shamburek R, Remaley A (2011) MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 13: 423-433.
  • Wahid F, Shehzad A, Khan T, Kim Y (2010) MicroRNAs: synthesis, mechanism, function and recent clinical trials. Biochim Biophys Acta 1803: 1231-1243. https://doi.org/10.1016/j.bbamcr.2010.06.013.
  • Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J, Qin YW, Jing Q (2010) Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J 31: 659-666.
  • Wang DZ (2008) An overview of microRNA. In RNA Technologies in Cardiovascular Medicine and Research. Erdmann V, Poller W, Barciszewski J eds, pp 4-12. Springer.
  • Winter J, Jung S, Keller S, Gregory RJ, Diederichs S (2009) Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11: 228-234.
  • Wu AH, Feng YJ (1998) Biochemical differences between cTnT and cTnI and their significance for diagnosis of acute coronary syndromes. Eur Heart J 19 (Suppl N): N25-N29.
  • Zampetaki A, Willeit P, Tilling L, Drozdov I, Prokopi M, Renard JM, Mayr A, Weger S, Schett G, Shah A, Boulanger CM, Willeit J, Chowienczyk PJ, Kiechl S, Mayr M (2012) Prospective study on circulating micrornas and risk of myocardial infarction. J Am Coll Cardiol 60: 290-299. https://doi.org/10.1016/j.jacc.2012.03.056.
  • Zeng L, Liu J, Wang Y, Wang L, Weng S, Tang Y, Zheng C, Cheng Q, Chen S, Yang GY (2011) MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia. Front Biosci (Elite Ed) 3: 1265-1272.
  • Zhang C (2008) MicroRNomics: a newly emerging approach for disease biology. Physiol Genomics 33: 139-147. https://doi.org/10.1152/physiolgenomics.00034.2008.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv63p725kz
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