A regulatory function of long non-coding RNAs in red blood cell development

• Authors: Klaudia Kulczyńska , Mirosława Siatecka
• Languages of publication: EN

Abstracts

EN

In recent years it has been discovered that long non-coding RNAs are important regulators in many biological processes. In this review, we summarize the role of lncRNA in erythropoiesis. lncRNA are crucial for regulation of gene expression during both, proliferation and differentiation stages of red blood cell development. Many are regulated by erythroid-specific transcription factors and some are expressed in a developmental stage-specific manner. The majority of individually studied lncRNAs are involved in regulating the terminal maturation stages of red cell differentiation. Their regulatory function is accomplished by various mechanisms, including direct regulation in cis or trans by the lncRNA product or by the cis-localized presence of the lncRNA transcription itself. These add additional levels of regulation of gene expression during erythropoiesis.

Keywords

EN

long non-coding RNA; erythropoiesis; red blood cells

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 4
• Pages: 675-680

Dates

published

2016

received

2016-06-03

revised

2016-07-24

accepted

2016-08-15

(unknown)

2016-11-17

Contributors

author

Klaudia Kulczyńska

• Department of Genetics, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University in Poznan, Poznań, Poland

author

Mirosława Siatecka

• Department of Genetics, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University in Poznan, Poznań, Poland

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Identifiers

DOI

10.18388/abp.2016_1351