Gastrodin ameliorates spinal cord injury via antioxidant and anti-inflammatory effects

• Authors: Fangtao Du , Xiaoning Wang , Bo Shang , Jifeng Fang , Yuting Xi , Aijuan Li , Yenze Diao
• Languages of publication: EN

Abstracts

EN

Spinal cord injury (SCI) is one of the most severe traumatic injuries that results in dysfunction of limbs and trunk below the damaged section. Recent studies have shown that gastrodin (GAS) could improve the recovery of SCI. In the current study, we aimed to examine the possible mechanism underlying the effect of GAS on recovery of SCI in rats. In rats with SCI, GAS improved locomotor functions and decreased permeability of blood-spinal cord barrier, as illustrated by increase of Basso-Beattie-Bresnahan scores and decrease of Evans blue leakage. In addition, GAS inhibited inflammation, as evidenced by decrease of proinflammatory cytokines, including tumor necrosis factor α (TNFα) and interleukin-1β (IL-1β) in rats following SCI. Moreover, increase of TBARS content and decrease of glutathione (GSH) content and superoxide dismutase (SOD) activities in SCI rats were inhibited by GAS. Furthermore, GAS enhanced mRNA expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), catalytic subunit of γ-glutamylcysteine ligase (GCLc) and modified subunit of γ-glutamylcysteine ligase (GCLm). The data suggested that GAS may promote the recovery of SCI through the enhancement of Nrf2-GCLc/GCLm signaling pathway, and subsequent improvement of oxidative stress and inflammation, resulting in decrease of permeability of BSCB and improved recovery of locomotor function in rats with SCI. The results have provided novel insights into GAS-related therapy of SCI and associated neurodegenerative diseases.

Keywords

EN

spinal cord injury; gastrodin; inflammation; oxidative stress; Nrf2

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 3
• Pages: 589-593

Dates

published

2016

received

2016-02-12

revised

2016-03-17

accepted

2016-05-19

(unknown)

2016-07-30

Contributors

author

Fangtao Du

• Department of Traumatic Orthopedics, The Second People's Hospital of Liaocheng, TaiShan Medical College, Liaocheng 252600, China

author

Xiaoning Wang

• Department of Orthopedics, The People's Hospital of Gaotang, Liaocheng 252800, China

author

Bo Shang

• Department of Traumatic Orthopedics, The Second People's Hospital of Liaocheng, TaiShan Medical College, Liaocheng 252600, China

author

Jifeng Fang

• Department of Traumatic Orthopedics, The Second People's Hospital of Liaocheng, TaiShan Medical College, Liaocheng 252600, China

author

Yuting Xi

• Department of Traumatic Orthopedics, The Second People's Hospital of Liaocheng, TaiShan Medical College, Liaocheng 252600, China

author

Aijuan Li

• Department of Outpatient, The Sixth People's Hospital of Weifang, Weifang 261021, China

author

Yenze Diao

• Department of Orthopedics, The Peking University Third Hospital, Beijing 100191, China

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Identifiers

DOI

10.18388/abp.2016_1272