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2016 | 63 | 3 | 527-531
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Hepatic expression of miR-122 and antioxidant genes in patients with chronic hepatitis B

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Introduction: The pathogenesis of chronic hepatitis B depends on both, the immune response and oxidative stress. Aim of the study: To assess the hepatic expression of miR-122 and the antioxidant genes: HMOX-1, NQO1 and GFER1, in liver biopsy specimens obtained from patients with chronic hepatitis B, with regard to selected clinical and histological parameters, using RT-PCR. Results: The study group comprised 34 HBV-infected patients. Statistically significant associations were found between lower hepatic expression of HMOX-1 and greater severity of liver inflammation (p=0.04). However, significantly higher expression of NQO1 was observed in patients with advanced liver fibrosis (p=0.035). Hepatic expression of miR-122 in HBV patients was not associated with viral load or liver injury. Conclusion: The hepatic expression of HMOX-1and NQO1 may be associated with liver injuries in chronic hepatitis B. However, hepatic expression of miR-122 does not seem to correspond to progression of the liver disease.
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  • Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland
  • Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland
  • Central Laboratory, Medical University of Lodz, Łódź, Poland
  • Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland
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