Virus-like particles as drug delivery vectors

• Authors: Michał Zdanowicz , Jadwiga Chroboczek
• Languages of publication: EN

Abstracts

EN

Virus-like particles (VLPs) assemble spontaneously during the viral cycle or in heterologous systems during expression of viral structural protein. Depending on the complexity of the VLPs, they can be obtained by expression in prokaryotic or eukaryotic expression system from the suitable recombinant vectors, or formed in cell-free conditions. Moreover, they can be built from proteins of a single virus, or can present the proteins or peptides derived from a virus or cell on a platform derived from any other single virus, thus forming chimeric VLPs. VLPs are best known for their immunogenic properties, but the versatility of VLPs allows a wide variety of applications. They are lately in the centre of investigations in vaccinology, drug delivery and gene therapy. This review focuses on utilization of VLPs for drug delivery.

Keywords

EN

VLPs; vaccines; virus

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 3
• Pages: 469-473

Dates

published

2016

received

2016-02-17

revised

2016-05-12

accepted

2016-05-15

(unknown)

2016-07-30

Contributors

author

Michał Zdanowicz

• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

author

Jadwiga Chroboczek

• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
• Therex, TIMC-IMAG, CNRS UMR 5525, UJF, Domaine de la Merci, 38700 La Tronche, France

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Identifiers

DOI

10.18388/abp.2016_1275