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2016 | 63 | 3 | 397-401
Article title

Curcumin augments the cytostatic and anti-invasive effects of mitoxantrone on carcinosarcoma cells in vitro

Content
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EN
Abstracts
EN
Numerous adverse effects limit the applicability of mitoxantrone for the treatment of drug-resistant tumors, including carcinosarcoma. Here, we estimated the additive effects of mitoxantrone and curcumin, a plant-derived biomolecule isolated from Curcuma longa, on the neoplastic and invasive potential of carcinosarcoma cells in vitro. Curcumin augmented the cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on the Walker-256 cells. It also strengthened the inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells that had retained viability after a long-term mitoxantrone/curcumin treatment. Thus, curcumin reduces the effective doses of mitoxantrone and augments its interference with the invasive potential of drug-resistant carcinosarcoma cells.
Year
Volume
63
Issue
3
Pages
397-401
Physical description
Dates
published
2016
received
2016-03-16
revised
2016-04-24
accepted
2016-05-06
(unknown)
2016-07-08
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv63p397kz
Identifiers
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