The links between hypertrophy, reproductive potential and longevity in the Saccharomyces cerevisiae yeast

• Authors: Mateusz Molon , Renata Zadrag-Tecza
• Languages of publication: EN

Abstracts

EN

The yeast Saccharomyces cerevisiae has long been used as a model organism for studying the basic mechanisms of aging. However, the main problem with the use of this unicellular fungus is the unit of "longevity". For all organisms, lifespan is expressed in units of time, while in the case of yeast it is defined by the number of daughter cells produced. Additionally, in yeast the phenotypic effects of mutations often show a clear dependence on the genetic background, suggesting the need for an analysis of strains representing different genetic backgrounds. Our results confirm the data presented in earlier papers that the reproductive potential is strongly associated with an increase in cell volume per generation. An excessive cell volume results in the loss of reproductive capacity. These data clearly support the hypertrophy hypothesis. The time of life of all analysed mutants, with the exception of sch9D, is the same as in the case of the wild-type strain. Interestingly, the 121% increase of the fob1D mutant's reproductive potential compared to the sfp1D mutant does not result in prolongation of the mutant's time of life (total lifespan).

Keywords

EN

yeast; lifespan; longevity; hypertrophy

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 2
• Pages: 329-334

Dates

published

2016

received

2015-08-01

revised

2016-01-17

accepted

2016-02-11

(unknown)

2016-02-29

Contributors

author

Mateusz Molon

• Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszów, Poland

author

Renata Zadrag-Tecza

• Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszów, Poland

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Identifiers

DOI

10.18388/abp.2015_1164