The relation between glutathione S-Transferase M1 null-genotype and cardiac problems in beta-thalassemia

• Authors: Asem Abo-Shanab , Mohamed El-Desouky , Naglaa Kholoussi , Ghada El-Kamah , Iman Helwa
• Languages of publication: EN

Abstracts

EN

This work was carried out to investigate the role of Glutathione S-Transferase M1 (GSTM1) null genotype frequency in prognosis of β-thalassemia, and to detect the correlation between GSTM1 null genotype and appearance of cardiac complications in β-thalassemia. Materials and Methods. The studied groups in the present work were divided to three groups (group I: 20 healthy subjects, group II: 56 β-thalassemic patients and group III: 16 β-thalassemic patients with cardiac complications were taken from group II). The measurement of human high sensitive C-reactive protein (hs-CRP) was performed using nephelometry. GSTM1 genotype was detected by Polymerase Chain Reaction (PCR) and cardiac complications were determined by using Echocardiography. Results. A statistically significant increase in hs-CRP and interleukin-6 (IL-6) levels was found in β-thalassemic patients with cardiac complications compared to normal subjects. Results showed no relation between GSTM1 null genotype frequency neither with β-thalassemia nor with cardiac complications appearance, where the interaction between GSTM1 null genotype in β-thalassemic patients with cardiac complications and healthy subjects were insignificant compared to subjects with GSTM1 non-null genotype. Conclusions. GSTM1 null genotype frequency has no role in β-thalassemia or cardiac complications appearance.

Keywords

EN

GSTM1; β-thalathemia; Cardiac complications; hs-CRP; IL-6

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 2
• Pages: 267-271

Dates

published

2016

received

2015-06-03

revised

2015-11-18

accepted

2016-01-13

(unknown)

2016-04-20

Contributors

author

Asem Abo-Shanab

• Department of Immunogenetics, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt

author

Mohamed El-Desouky

• Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt

author

Naglaa Kholoussi

• Department of Immunogenetics, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt

author

Ghada El-Kamah

• Department of Clinical Genetics, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt

author

Iman Helwa

• Department of Immunogenetics, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt

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Identifiers

DOI

10.18388/abp.2015_1076