Association between depression, parameters of adiposity and genetic polymorphisms of pro-inflammatory cytokines: IL-1α, IL-1β, IL-2 and IL-6 in subjects over 55 years old

• Authors: Grażyna Adler , Karolina Skonieczna-Żydecka , Agnieszka Madlani , Jarosław Ogonowski , Elżbieta Grochans , Joanna Pierzak-Sominka , Jacek Brodowski , Beata Karakiewicz
• Languages of publication: EN

Abstracts

EN

Background. During the last few decades, adiposity has become a relatively common phenomenon worldwide. The available data on the effects of pro-inflammatory factors in both depression and adiposity has been attracting great attention. Aim. We sought to assess the prevalence of -889C>T IL-1α, -31T>C and -511C>T IL-1β, -330T>G IL-2 and -174G>C IL-6 genes and their association with adiposity and depression in Polish subjects. Methods. A cohort study was conducted in 2013/2014, covering a sample of 297 individuals (217 female and 80 male). Anthropometric data was handled using the BIA analysis method, while for genotyping PCR-RFLP techniques were used. Results. A positive correlation between depression and anthropometric parameters: adipose tissue (in kg) and adipose tissue (in %) (R=0.135 and p=0.02, R=0.114 and p<0.05, respectively) was found. No association between studied polymorphisms and depression was observed. Conclusion. Although it was not possible to demonstrate any influence of the studied polymorphisms as the genetic modulator of depression, authors believe that the presented data are noticeable and may provide the basis for future studies on larger groups.

Keywords

EN

cross sectional study; genetic variants of cytokines; obesity; depression

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 2
• Pages: 253-259

Dates

published

2016

received

2015-05-14

revised

2016-01-14

accepted

2016-02-21

(unknown)

2016-03-02

Contributors

author

Grażyna Adler

• Department of Gerontobiology, Pomeranian Medical University, Szczecin, Szczecin, Poland

author

Karolina Skonieczna-Żydecka

• Department of Gerontobiology, Pomeranian Medical University, Szczecin, Szczecin, Poland

author

Agnieszka Madlani

• Department of Gerontobiology, Pomeranian Medical University, Szczecin, Szczecin, Poland

author

Jarosław Ogonowski

• Department of Civilization Diseases, Pomeranian Medical University, Szczecin, Poland

author

Elżbieta Grochans

• Department of Nursing, Pomeranian Medical University, Szczecin, Poland

author

Joanna Pierzak-Sominka

• Department of Public Health, Pomeranian Medical University, Szczecin, Poland

author

Jacek Brodowski

• Laboratory of Primary Health Care, Pomeranian Medical University, Szczecin, Poland

author

Beata Karakiewicz

• Chair and Department of Public Health, Pomeranian Medical University, Szczecin, Poland

References

• Akbaraly TN, Kivimaki M, Brunner EJ, Chandola T, Marmot MG, Singh-Manoux A, Ferrie JE (2009) Association between metabolic syndrome and depressive symptoms in middle-aged adults: results from the Whitehall II study. Diabetes Care 32: 499-504. doi: 10.2337/dc08-1358.
• Albiński R, Kleszczewska-Albińska A, Bedyńska S (2011) Geriatryczna Skala Depresji (GDS). Trafność i rzetelność różnych wersji tego narzędzia - przegląd badań. Psychiatr Pol 45: 555-562 (in Polish).
• Arrieta MC, Bistritz L, Meddings JB (2006) Alterations in intestinal permeability. Gut 55: 1512-1520.
• Barreira TV, Harrington DM, Staiano AE, Heymsfield SB, Katzmarzyk PT (2011) Body adiposity index, body mass index, and body fat in white and black adults. JAMA 306: 828-830.
• Basterzi AD, Aydemir C, Kisa C, Aksaray S, Tuzer V, Yazici K, Göka E (2005) IL-6 levels decrease with SSRI treatment in patients with major depression. Hum Psychopharmacol 20: 473-476.
• Baumeister H, Harter M (2007) Mental disorders in patients with obesity in comparison with healthy probands. Int J Obes (Lond) 31: 1155-1164.
• Beisel WR (1981) Impact of infectious disease upon fat metabolism and immune functions. Cancer Res 41: 3797-3798.
• Besedovsky HO, del Rey A (1996) Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev 17: 64-102.
• Borkowska P, Kucia K, Rzezniczek S, Paul-Samojedny M, Kowalczyk M, Owczarek A, Suchanek R, Medrala T, Kowalski J (2011) Interleukin-1beta promoter (-31T/C and -511C/T) polymorphisms in major recurrent depression. J Mol Neurosci 44: 12-16. doi: 10.1007/s12031-011-9507-5.
• Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P, Posthuma D, van Veen T, Willemsen G, DeRijk RH, de Geus EJ, Hoogendijk WJ, Sullivan PF, Penninx BW, Boomsma DI, Snieder H, Nolen WA (2011) Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol Psychiatry 16: 516-532. doi: 10.1038/mp.2010.38.
• Bouchard C (2007) BMI, fat mass, abdominal adiposity and visceral fat: where is the 'beef?' Int J Obes (Lond) 31: 1552-1553.
• Bufalino C, Hepgul N, Aguglia E, Pariante CM (2012) The role of immune genes in the association between depression and inflammation: A review of recent clinical studies. Brain Behav Immun 31: 31-47. doi: 10.1016/j.bbi.2012.04.009.
• Buret AG (2006) How stress induces intestinal hypersensitivity. Am J Pathol 168: 3-5.
• Camhi SM, Bray GA, Bouchard C, Greenway FL, Johnson WD, Newton RL, Ravussin E, Ryan DH, Smith SR, Katzmarzyk PT (2011) The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race differences. Obesity (Silver Spring) 19: 402-408. doi: 10.1038/oby.2010.248.
• Cartier A, Bergeron J, Poirier P, Almeras N, Tremblay A, Lemieux I, Despres JP (2009) Increased plasma interleukin-1 receptor antagonist levels in men with visceral obesity. Ann Med 41: 471-478. doi: 10.1080/07853890903022801.
• Chung S, Lapoint K, Martinez K, Kennedy A, Boysen Sandberg M, McIntosh MK (2006) Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 147: 5340-5351.
• De Berardis D, Conti CM, Serroni N, Moschetta FS, Olivieri L, Carano A, Salerno RM, Cavuto M, Farina B, Alessandrini M, Janiri L, Pozzi G, Di Giannantonio M (2010) The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol 23: 417-422.
• Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246: 199-229. doi: 10.1016/j.neuroscience.2013.04.060.
• Chung YJ, Penner KM, Pestka JJ, North CM, Claycombe KJ (2004) Expression of interleukin-6 is greater in preadipocytes than in adipocytes of 3T3-L1 cells and C57BL/6J and ob/ob mice. J Nutr 134: 2673-2677.
• Clement K, Basdevant A (2010) Pathophysiological aspects of human obesity - what we know in 2010. European Endocrinology 6: 10-16. doi: 10.1210/jc.2009-1912.
• Cohen BE, Panguluri P, Na B, Whooley MA (2010) Psychological risk factors and the metabolic syndrome in patients with coronary heart disease: findings from the Heart and Soul Study. Psychiatry Research 175: 133-137. doi: 10.1016/j.psychres.2009.02.004.
• Corwin EJ, Johnston N, Pugh L (2008) Symptoms of postpartum depression associated with elevated levels of interleukin-1 beta during the first month postpartum. Biol Res Nurs 10: 128-133. doi: 10.1177/1099800408323220.
• De Wit L, Luppino F, Van Straten A, Penninx B, Zitman F, Cuijpers P (2010) Depression and obesity: a meta-analysis of community-based studies. Psychiatry Res 178: 230-235. doi: 10.1016/j.psychres.2009.04.015.
• Diniz BS, Teixeira AL, Talib L, Gattaz WF, Forlenza OV (2010) Interleukin-1beta serum levels is increased in antidepressant--free elderly depressed patients. Am J Geriatr Psychiatry 18: 172-176. doi: 10.1097/JGP.0b013e3181c2947f.
• Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67: 446-457. doi: 10.1016/j.biopsych.2009.09.033.
• Dunn AJ, Swiergiel AH, de Beaurepaire R (2005) Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev 29: 891-909.
• Gao QJ, Liu DW, Zhang SY, Jia M, Wang LM, Wu LH, Wang SY, Tong LX (2009) Polymorphisms of some cytokines and chronic hepatitis B and C virus infection. World J Gastroenterol 15: 5610-5619.
• Haroon E, Raison CL, Miller AH (2012) Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37: 137-162. doi: 10.1038/npp.2011.205.
• Heo M, Pietrobelli A, Fontaine KR, Sirey JA, Faith MS (2006) Depressive mood and obesity in US adults: comparison and moderation by sex, age, and race. Int J Obes (Lond) 30: 513-519.
• Herva A, Laitinen J, Miettunen J, Veijola J, Karvonen JT, Läksy K, Joukamaa M (2006) Obesity and depression: results from the longitudinal Northern Finland 1966 Birth Cohort Study. Int J Obes (Lond) 30: 520-527.
• Howe LR, Subbaramaiah K, Hudis CA, Dannenberg AJ (2013) Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer. Clin Cancer Res 19: 6074-6083. doi: 10.1158/1078-0432.CCR-12-2603.
• Howren MB, Lamkin DM, Suls J (2009) Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 71: 171-186. doi: 10.1097/PSY.0b013e3181907c1b.
• Hwang JP, Tsai SJ, Hong CJ, Yang CH, Hsu CD, Liou YJ (2009) Interleukin-1 beta -511C/T genetic polymorphism is associated with age of onset of geriatric depression. Neuromolecular Med 11: 322-327. doi: 10.1007/s12017-009-8078-x.
• Jackson AS, Stanforth PR, Gagnon J, Rankinen T, Leon AS, Rao DC, Skinner JS, Bouchard C, Wilmore JH (2002) The effect of sex, age and race on estimating percentage body fat from body mass index: the Heritage Family Study. Int J Obes Relat Metab Disord 26: 789-796.
• Khairova RA, Machado-Vieira R, Du J, Manji HK (2009) A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol 12: 561-578. doi: 10.1017/S1461145709009924.
• Khaodhiar L, Ling PR, Blackburn GL, Bistrian BR (2004) Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity. JPEN J Parenter Enteral Nutr 28: 410-415.
• Lee YK, Mazmanian SK (2010) Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 330: 1768-1773. doi: 10.1126/science.1195568.
• Lim W, Hong S, Nelesen R, Dimsdale JE (2005) The association of obesity, cytokine levels, and depressive symptoms with diverse measures of fatigue in healthy subjects. Arch Intern Med 165: 910-915.
• Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG (2010) Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 67: 220-229. doi: 10.1001/archgenpsychiatry.2010.2.
• Maes M, Mihaylova I, Kubera M, Ringel K (2012) Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. Prog Neuropsychopharmacol Biol Psychiatry 36: 169-175. doi: 10.1016/j.pnpbp.2011.09.006.
• Maes M, Song C, Yirmiya R (2012) Targeting IL-1 in depression. Expert Opin Ther Targets 16: 1097-1112. doi: 10.1517/14728222.2012.718331.
• Martinac M, Pehar D, Karlovic D, Babic D, Marcinko D, Jakovljevic M (2014) Metabolic syndrome, activity of the hypothalamic-pituitary-adrenal axis and inflammatory mediators in depressive disorder. Acta Clin Croat 53: 55-71.
• Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: the role of cytokines in the Pathophysiology of Major depression. Biol Psychiatry 65: 732-741. doi: 10.1016/j.biopsych.2008.11.029.
• Miller GE, Freedland KE, Carney RM, Stetler CA, Banks WA (2003) Pathways linking depression, adiposity, and inflammatory markers in healthy young adults. Brain Behav Immun 17: 276-285.
• Misener VL, Gomez L, Wigg KG, Luca P, King N, Kiss E, Daroczi G, Kapornai K, Tamas Z, Mayer L, Gadoros J, Baji I, Kennedy JL, Kovacs M, Vetro A, Barr CL (2008) International Consortium for Childhood - Onset Mood Disorders Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood - onset mood disorders. Neuropsychobiology 58: 71-80. doi: 10.1159/000159775.
• O'Brien SM, Scott LV, Dinan TG (2004) Cytokines: abnormalities in major depression and implications for pharmacological treatment. Hum Psychopharmacol 19: 397-403.
• Ogbera AO (2010) Prevalence and gender distribution of the metabolic syndrome. Diabetol Metab Syndr 2: 1. doi: 10.1186/1758-5996-2-1.
• Park HS, Park JY, Yu R (2005) Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 69: 29-35.
• Paz Aparicio J, Fernandez Bances I, Lopez-Anglada Fernandez E, Montes AH, Paz Aparicio A, Pena Vazquez J, Ramos Garcia S, Anton Garcia S, Lopez Fernandez P, Valle-Garay E, Asensi V (2011) The IL-1β (+3953 T/C) gene polymorphism associates to symptomatic lumbar disc herniation. Eur Spine J 20 (Suppl 3): 383-389. doi: 10.1007/s00586-011-1915-2.
• Pizzagalli DA, Holmes AJ, Dillon DG, Goetz EL, Birk JL, Bogdan R, Dougherty DD, Iosifescu DV, Rauch SL, Fava M (2009) Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder. Am J Psychiatry 166: 702-710. doi: 10.1176/appi.ajp.2008.08081201.
• Raison CL, Borisov AS, Majer M, Drake DF, Pagnoni G, Woolwine BJ, Vogt GJ, Massung B, Miller AH (2009) Activation of central nervous system inflammatory pathways to interferon-alpha: relationship is monoamines and depression. Biol Psychiatry 65: 296-303. doi: 10.1016/j.biopsych.2008.08.010.
• Raison CL, Miller AH (2013) The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D). Mol Psychiatry 18: 15-37. doi: 10.1038/mp.2012.2.
• Schiepers OJ, Wichers MC, Maes M (2005) Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry 29: 201-217.
• Schmidt FM, Lichtblau N, Minkwitz J, Chittka T, Thormann J, Kirkby KC, Sander C, Mergl R, Faßhauer M, Stumvoll M, Holdt LM, Teupser D, Hegerl U, Himmerich H (2014) Cytokine levels in depressed and non-depressed subjects, and masking effects of obesity. J Psychiatr Res 55: 29-34. doi: 10.1016/j.jpsychires.2014.04.021.
• September AV, Nell EM, O'Connell K, Cook J, Handley CJ, van der Merwe L, Schwellnus M, Collins M (2011) A pathway-based approach investigating the genes encoding interleukin-1β, interleukin-6 and the interleukin-1 receptor antagonist provides new insight into the genetic susceptibility of Achilles tendinopathy. Br J Sports Med 45: 1040-1047. doi: 10.1136/bjsm.2010.076760.
• Silverman MN, Pearce BD, Biron CA, Miller AH (2005) Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection. Viral Immunol 18: 41-78.
• Simon GE, Ludman EJ, Linde JA, Operskalski BH, Ichikawa L, Rohde P, Finch EA, Jeffery RW (2008) Association between obesity and depression in middle-aged women. Gen Hosp Psychiatry 30: 32-39. doi: 10.1016/j.genhosppsych.2007.09.001.
• Sluzewska A, Rybakowski J, Bosmans E, Sobieska M, Berghmans R, Maes M, Wiktorowicz K (1996) Indicators of immune activation in major depression. Psychiatry Res 64: 161-167.
• Suganami T, Ogawa Y (2010) Adipose tissue macrophages: their role in adipose tissue remodeling. J Leukoc Biol 88: 33-39. doi: 10.1189/jlb.0210072.
• Takeuchi T, Nakao M, Nomura K, Inoue M, Tsurugano S, Shinozaki Y, Yano E (2009) Association of the metabolic syndrome with depression and anxiety in Japanese men: a 1-year cohort study. Diabetes Metab Res Rev 25: 762-767. doi: 10.1002/dmrr.1041.
• Todhunter CE, Sutherland-Craggs A, Bartram SA, Donaldson PT, Daly AK, Francis RM, Mansfield JC, Thompson NP (2005) Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease. Gut 54: 1579-1584.
• Ufnal M, Wolynczyk-Gmaj D (2011) The brain and cytokines - the mutual origin of depression, obesity and cardiovascular diseases? Postepy Hig Med Dosw (Online) 65: 228-235.
• Ujcic-Voortman JK, Baan CA, Seidell JC, Verhoeff AP (2012) Obesity and cardiovascular disease risk among Turkish and Moroccan migrant groups in Europe: a systematic review. Obesity Reviews 13: 2-16. doi: 10.1111/j.1467-789X.2011.00932.x.
• Um JY, Rim HK, Kim SJ, Kim HL, Hong SH (2011) Functional polymorphism of IL-1 alpha and its potential role in obesity in humans and mice. PLoS One 6: e29524. doi: 10.1371/journal.pone.0029524.
• Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808.
• Wellen KE, Hotamisligil GS (2003) Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112: 1785-1788.
• World Health Organization. Obesity and overweight. Fact sheet N°311, updated Februar 2015. Available from. http://www.who.int/mediacentre/factsheets/fs311/en/.
• Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO (1983) Development and validation of a geriatric depression screening scale: A preliminary report. J Psychiatr Res 17: 37-49.
• Yu YW, Chen TJ, Hong CJ, Chen HM, Tsai SJ (2003) Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response. Neuropsychopharmacology 28: 1182-1185.

Identifiers

DOI

10.18388/abp.2015_1063