Classifying lipoproteins based on their polar profiles

• Authors: Carlos Polanco , Jorge Castañón-González , Thomas Buhse , Vladimir Uversky , Rafael Amkie
• Languages of publication: EN

Abstracts

EN

The lipoproteins are an important group of cargo proteins known for their unique capability to transport lipids. By applying the Polarity index algorithm, which has a metric that only considers the polar profile of the linear sequences of the lipoprotein group, we obtained an analytical and structural differentiation of all the lipoproteins found in UniProt Database. Also, the functional groups of lipoproteins, and particularly of the set of lipoproteins relevant to atherosclerosis, were analyzed with the same method to reveal their structural preference, and the results of Polarity index analysis were verified by an alternate test, the Cumulative Distribution Function algorithm, applied to the same groups of lipoproteins.

Keywords

EN

potential of association; lipoproteins; polar balance; polarity index method; unfolded proteins; folded proteins; partially folded proteins; intrinsically disordered proteins; atherosclerosis

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 2
• Pages: 235-241

Dates

published

2016

received

2014-10-15

revised

2015-12-30

accepted

2016-02-23

(unknown)

2016-04-08

Contributors

author

Carlos Polanco

• Department of Mathematics, Faculty of Sciences, Universidad Nacional Autónoma de México, C.P. 04510 D.F., México

author

Jorge Castañón-González

• Departments of Critical Care Medicine and Biomedical Research, Hospital Juárez de México, D.F. 07760 México

author

Thomas Buhse

• Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, C.P. 62209 Chamilpa, Cuernavaca, Morelos, México

author

Vladimir Uversky

• Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, MDC07 Tampa, FL 33647, USA
• Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
• Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia

author

Rafael Amkie

• Faculty of Health Sciences, Universidad Anahuac, C.P. 52786 Huixquilucan Estado de Mexico, México

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Identifiers

DOI

10.18388/abp.2014_918