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2016 | 63 | 2 | 229-233
Article title

Structure and function relationships of proteins based on polar profile: a review

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Abstracts
EN
Proteins in the post-genome era impose diverse research challenges, the main are the understanding of their structure-function mechanism, and the growing need for new pharmaceutical drugs, particularly antibiotics that help clinicians treat the ever- increasing number of Multidrug-Resistant Organisms (MDROs). Although, there is a wide range of mathematical-computational algorithms to satisfy the demand, among them the Quantitative Structure-Activity Relationship algorithms that have shown better performance using a characteristic training data of the property searched; their performance has stagnated regardless of the number of metrics they evaluate and their complexity. This article reviews the characteristics of these metrics, and the need to reconsider the mathematical structure that expresses them, directing their design to a more comprehensive algebraic structure. It also shows how the main function of a protein can be determined by measuring the polarity of its linear sequence, with a high level of accuracy, and how such exhaustive metric stands as a "fingerprint" that can be applied to scan the protein regions to obtain new pharmaceutical drugs, and thus to establish how the singularities led to the specialization of the protein groups known today.
Publisher

Year
Volume
63
Issue
2
Pages
229-233
Physical description
Dates
published
2016
received
2014-10-15
revised
2016-01-19
accepted
2016-02-23
(unknown)
2016-04-08
Contributors
  • Department of Mathematics, Faculty of Sciences, Universidad Nacional Autónoma de México, C.P. 04510 D.F., México
author
  • Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, C.P. 62209 Chamilpa, Cuernavaca, Morelos, México
  • Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, MDC07 Tampa, FL 33647, USA
  • Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
  • Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv63p229kz
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