Stress granules (SG) and processing bodies (PB) in viral infections

• Authors: Magdalena Malinowska , Paulina Niedźwiedzka-Rystwej , Beata Tokarz-Deptuła , Wiesław Deptuła
• Languages of publication: EN

Abstracts

EN

During reaction to stress caused by viral infection, RNA granules are formed in order to protect mRNA. Stress granules (SG) and processing bodies (PB) provide cell homeostasis and mRNA stability. They are formed, for example, during polio virus and MRV (mammalian orthoreovirus) infections. Some viruses, such as influenza virus and HTLV-1 (Human T-lymphotropic virus 1), block the formation of granules. In addition, there are viruses like West Nile Virus, Hepatitis C Virus (HCV) or human Herpes viruses, which influence the functioning of the granules.

Keywords

EN

stress granules; processing bodies; viral infection

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 2
• Pages: 183-188

Dates

published

2016

received

2015-05-12

revised

2015-12-18

accepted

2016-01-21

(unknown)

2016-02-19

Contributors

author

Magdalena Malinowska

• Department of Immunology, Faculty of Biology, University of Szczecin

author

Paulina Niedźwiedzka-Rystwej

• Department of Immunology, Faculty of Biology, University of Szczecin

author

Beata Tokarz-Deptuła

• Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland

author

Wiesław Deptuła

• Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland

References

• Anderson P, Kedersha N (2008) Stress granules: the Tao of RNA triage. Trends Biochem Sci 33: 141-150. doi: 10.1016/j.tibs.2007.12.003.
• Andrei MA, Ingelfinger D, Heintzmann R, Achsel T, Rivera-Pomar R, Lührmann R (2005) A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. RNA 11: 717-727.
• Antar LN, Dictenberg JB, Plociniak M, Afroz R, Bassell GJ (2005) Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neurons. Genes Brain Behav 4: 350-359.
• Baez MV, Boccaccio GL (2005) Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. J Biol Chem 280: 43131-43140.
• Balagopal V, Parker R (2009) Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs. Curr Opin Cell Biol 21: 403-408. doi: 10.1016/j.ceb.2009.03.005.
• Beckham CJ, Parker R (2008) P bodies, stress granules and viral life cycle. Cell Host Microbe 3: 206-212. doi: 10.1128/JVI.00647-12.
• Berlanga JJ, Ventoso I, Harding HP, Deng J, Ron D, Sonenberg N, Carrasco L, de Haro C (2006) Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. EMBO J 25: 1730-1740.
• Borghese F, Michiels T (2011) The leader protein of cardioviruses stress granule assembly. J Virol 85: 9614-9622. doi: 10.1128/JVI.00480-11.
• Deigendesch N, Koch-Nolte F, Rothenburg S (2006) ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains. Nucleic Acids Res 34: 5007-5020.
• Dougherty JD, White JP, Lloyd RE (2011) Poliovirus-mediated disruption of cytoplasmic processing bodies. J Virol 85: 64-75. doi: 10.1128/JVI.01657-10.
• Emara MM, Brinton MA (2007) Interaction of TIA-1/TIAR with West Nile and Dengue virus products in infected cells interferes with stress granules formation and processing body assembly. Proc Natl Acad Sci USA 104: 9041-9046.
• Eulalio A, Behm-Ansmant I, Schweizer D, Izaurralde E (2007) P-body formation is a consequence, not the cause of RNA-mediated gene silencing. Mol Cell Biol 27: 3970-3981.
• Gaillard H, Aguilera A (2008) A novel class of mRNA-containing cytoplasmic granules are produced in response to UV-irradiation. Mol Biol Cell 19: 4980-4992. doi: 10.1091/mbc.E08-02-0193/.
• Garber K, Smith KT, Reines D, Warren ST (2006) Transcription, translation and fragile X syndrome. Curr Opin Genet Dev 16: 270-275.
• Hebner CM, Wilson R, Rader J, Bidder M, Laimins LA (2006) Human papillomaviruses target the double-stranded RNA protein kinase pathway. J Gen Virol 87: 3183-3193.
• Hoyle NP, Castelli LM, Campbell SG, Holmes LE, Ashe MP (2007) Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies. J Cell Biol 179: 65-74.
• Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W, Matsuura Y (2013) Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilities viral propagation. J Virol 87: 489-502. doi: 10.1128/JVI.02186-12.
• Kedersha N, Chen S, Gilks N, Li W, Miller IJ, Stahl J, Anderson P (2002) Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules. Mol Biol Cell 13: 195-210.
• Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P (2005) Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol 169: 871-884.
• Kedersha N, Gupta M, Li W, Miller I, Anderson P (1999) RNA-binding proteins TIA-1 and TIAR link the phopsorylation of eIF-2 alpha to the assembly of mammalian stress granules. J Cell Biol 147: 1431-1442.
• Khaperskyy DA, Hatchette TF, McCormick C (2012) Influenza A virus inhibits cytoplasmic stress granule formation. FASEB J 26: 1629-1639. doi: 10.1096/fj.11-196915.
• Khaperskyy DA, Emara MM, Johnston BP, Anderson P, Hatchette TF, McCormick C (2014) Influenza A virus host shutoff disables antiviral stress-induced translation arrest. PLoS Pathog 10: e1004217. doi: 10.1371/journal.ppat.1004217.
• Kimball SR, Horetsky RL, Ron D, Jefferson LS, Harding HP (2003) Mammalian stress granules represent sites of accumulation of stalled translation initiation complex. Am J Physiol Cell Physiol 284: C273-C284.
• Kwon S, Zhang Y, Matthias P (2007) The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev 21: 3381-3394.
• Li W, Li Y, Kedersha N, Anderson P, Emara M, Świderek KM, Moreno GT, Brinton MA (2002) Cell proteins TIA-1 and TIAR interect the 3'stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication. J Virol 76: 11989-2000.
• Lindquist M, Lifland AW, Utley TJ, Santangelo PJ, Crowe JE Jr (2010) Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication. J Virol 84: 12274-12284. doi: 10.1128/JVI.00260-10.
• Lindquist ME, Mainou BA, Dermody TS, Crowe JE Jr (2011) Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication. Virology 413: 103-110. doi: 10.1016/j.virol.2011.02.009.
• Lui J, Castelli LM, Pizzinga M, Simpson CE, Hoyle NP, Bailey KL, Campbell SG, Ashe MP (2014) Granules harboring translationally active mRNAs provide a platform for P-bodies formation following stress. Cell Rep 9: 944-954 doi: 10.1016/j.celrep.2014.09.040.
• McInerney GM, Kedersha NL, Kaufman RJ, Anderson P, Liljeström P (2005) Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation. Mol Biol Cell 16: 3753-3763.
• Moeller BJ, Cao Y, Li CY, Dewhirst MW (2004) Radiation activates HIF-1 to regulate vascular radiosensivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441.
• Monani UR (2005) Spinal muscular atrophy: a deficiency in a ubiquitous protein. Neuron 48: 885-896.
• Montero H, Rojas M, Arias CF, López S (2008) Rotavirus infection induces the pfosphorylation of eIF2alpha but prevents the formation of stress granules. J Virol 82: 1496-1504.
• Morris AR, Mukherjee N, Keene JD (2008) Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets. Mol Cell Biol 28: 4093-4103. doi: 10.1128/MCB.00155-08.
• Niedźwiedzka-Rystwej P, Tokarz-Deptuła B, Deptuła W (2015) RNA Granules - homeostasis regulator factors and new factors of resistance. Postępy Hig Med Dośw, in press (in Polish).
• Okonski KM, Samuel CE (2013) Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1. J Virol 87: 756-766. doi: 10.1128/JVI.02270-12.
• Onomoto K, Yoneyama M, Fung G, Kato H, Fujita T (2014) Antiviral innate immunity and stress granule responses. Trends Immunol 35: 420-428. doi: 10.1016/j.it.2014.07.006.
• Qin Q, Hastings C, Miller CL (2009) Mammalian orthoreovirus particles induce and are recruited into stress granules at early times postinfection. J Virol 83: 11090-11101. doi: 10.1128/JVI.01239-09.
• Reineke LC, Lloyd R (2013) Diversion of stress granules and P-bodies during viral infection. Virology 436: 255-267. doi: 10.1016/j.virol.2012.11.017.
• Robbins PD, Morelli AE (2014) Regulation of immune response by extracellular vesicles. Nat Rev Immunol 14: 195-208 doi: 10.1038/nri3622.
• Toroney R, Nallagatla SR, Boyer JA, Cameron CE, Bevilacqua PC (2010) Regulation of PKR by HCV IRES RNA: importance of domain II and NS5A. J Mol Biol 400: 393-413. doi: 10.1016/j.jmb.2010.04.059.
• Tourriere H, Chebli K, Zekri L, Courselaud B, Blanchard JM, Bertrand E, Tazi J (2003) The RasGAP-associated endoribonuclease G3BP assembles stress granules. J Cell Biol 160: 823-831.
• Valiente-Echeverria F, Melnychuk L, Mouland AJ (2012) Viral modulation of stress granules. Virus Res 169: 430-437. doi: 10.1016/j.virusres.2012.06.004.
• Weissbach R, Scadden AD (2007) Tudor-SN and ADAR1 are components of cytoplasmic stress granules. RNA 18: 462-471. doi: 10.1261/rna.027656.111.
• White JP, Lloyd RE (2012) Regulation of stress granules in virus systems. Trends Microbiol 20: 175-183. doi: 10.1016/j.tim.2012.02.001.
• Wichroski MJ, Robb GB, Rana TM (2006) Human retroviral host restriction factors APOBEC3G and APOBEC3F localiza to mRNA processing bodies. PLoS Pathog 2: e41.
• Wilusz CJ, Wilusz J (2004) Bringing the role of mRNA decay in the control of gene expression into focus. Trends Genet 20: 491-497.
• Yang WH, Yu JH, Gulick T, Bloch KD, Bloch DB (2006) RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules. RNA 12: 547-554.
• Yu JH, Yang WH, Gulick T, Bloch KD, Bloch DB (2005) Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body. RNA 11: 1795-1802.

Identifiers

DOI

10.18388/abp.2015_1060