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2015 | 62 | 1 | 7-13
Article title

Heavy metals in the cell nucleus - role in pathogenesis

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EN
Abstracts
EN
People are exposed to heavy metals both in an occupational and natural environment. The most pronounced effects of heavy metals result from their interaction with cellular genetic material packed in form of chromatin. Heavy metals influence chromatin, mimicking and substituting natural microelements in various processes taking place in the cell, or interacting chemically with nuclear components: nucleic acids, proteins and lipids. This paper is a review of current knowledge on the effects of heavy metals on chromatin, exerted at the level of various nuclear components.
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EN
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Year
Volume
62
Issue
1
Pages
7-13
Physical description
Dates
published
2015
received
2014-06-11
revised
2014-11-29
accepted
2015-01-09
online
2015-02-04
Contributors
  • Nencki Institute of Experimental Biology PAS, Warszawa, Poland
  • Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland
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