PL EN


Preferences help
enabled [disable] Abstract
Number of results
2015 | 62 | 4 | 739-745
Article title

The effects of nickel(II) complexes with imidazole derivatives on pyocyanin and pyoverdine production by Pseudomonas aeruginosa strains isolated from cystic fibrosis

Content
Title variants
Languages of publication
EN
Abstracts
EN
Pseudomonas aeruginosa infection is problematic in patients with cystic fibrosis (CF). P. aeruginosa secretes a diversity of pigments, such as pyocyanin and pyoverdine. The aim of this study was to evaluate the effects of complexes of nickel(II) ([Ni(iaa)2(H2O)2]·H2O (iaa = imidazole-4-acetate anion), [Ni(1-allim)6](NO3)2 (1-allim = 1-allylimidazole) and NiCl2 on pyocyanin and pyoverdine production by 23 strains of P. aeruginosa isolated from cystic fibrosis under growth conditions specific for the CF respiratory system. The antibacterial effects and biophysical properties of the tested substances were measured by spectrofluorometric techniques, as well as by laser interferometry, confocal and atomic force microscopy. The cytotoxic properties of all compounds were measured by Annexin/IP assay against A549 cells. All tested compounds have no effect on pyocyanin production and decrease the pyoverdine secretion in about 40% of tested P. aeruginosa strains at non-cytotoxic range of concentrations. Imidazole-4-acetate anion and 1-allylimidazole have good diffusion properties in the mature P. aeruginosa PAO1 biofilm. In conclusion, the tested nickel(II) complexes do not have clinical implications in P. aeruginosa eradication in cystic fibrosis. The diffusion properties of 1-allylimidazole and imidazole-4-acetate and their lack of effect on A549 cells suggest that they might be considered for chemical synthesis with other transition metals.
Publisher

Year
Volume
62
Issue
4
Pages
739-745
Physical description
Dates
published
2015
received
2015-07-22
revised
2015-10-26
accepted
2015-11-30
(unknown)
2015-12-08
Contributors
  • Department of Microbiology, Institute of Biology, Jan Kochanowski University, Kielce, Poland
  • Institute of Chemistry, Jan Kochanowski University, Kielce, Poland
  • Department of Environment Protection and Modelling, Jan Kochanowski University, Kielce, Poland
  • Institute of Physics, Jan Kochanowski University in Kielce, Kielce, Poland
author
  • Institute of Physics, Jan Kochanowski University in Kielce, Kielce, Poland
author
  • Institute of Physics, Jan Kochanowski University in Kielce, Kielce, Poland
  • Department of Radiobiology and Immunology, Jan Kochanowski University, Kielce, Poland
author
  • Department of Radiobiology and Immunology, Jan Kochanowski University, Kielce, Poland
  • Centre for Radiobiology and Biological Dosimetry, Institute for Nuclear Chemistry and Technology, Warsaw, Poland
  • Department of Microbiology, Institute of Biology, Jan Kochanowski University, Kielce, Poland
References
  • Arabski M, Wąsik S, Dworecki K, Kaca W (2007) Laser interferometric determination of ampicillin and colistin transfer through cellulose biomembrane in the presence of Proteus vulgaris O25 lipopolysaccharide. J Memb Sci 299: 268-275.
  • Arabski M, Davydova VN, Wąsik S, Reunov AV, Lapshina LA, Yermak IM, Kaca W (2009a) Binding of lipopolysaccharide from Proteus vulgaris O25 (48/57) with chitosan. Carbohydr Polym 78: 481-487.
  • Arabski M, Wąsik S, Dworecki K, Kaca W (2009b) Laser interferometric and cultivation methods for measurement of colistin/ampicilin and saponin interactions with smooth and rough of Proteus mirabilis lipopolysaccharides and cells. J Microbiol Methods 77: 178-183.
  • Arabski M, Wąsik S, Drulis-Kawa Z (2013a) Laser interferometry analysis of ciprofloxacin diffusion through Pseudomonas aeruginosa biofilm. Clin Microbial 2: 105.
  • Arabski M, Wasik S, Zych M, Lakomiec W, Kaca W (2013b) Analysis of ciprofloxacin and gentamicin diffusion in Proteus mirabilis O18 biofilm by laser interferometry method. Acta Biochim Pol 60: 707-711.
  • Danis-Wlodarczyk K, Olszak T, Arabski M, Wasik S, Majkowska-Skrobek G, Augustyniak D, Gula Gr, Briers Y, Jang HB, Vandenheuvel D, Duda KA, Lavigne R, Drulis-Kawa Z (2015) Characterization of the newly isolated lytic bacteriophages KTN6 and KT28 and their efficacy against Pseudomonas aeruginosa biofilm. PloS One 10: e0127603.
  • Darzynkiewicz Z (2003) Current protocols in Cell Biology, John Wiley & Sons, Inc.
  • De Soyza A, Hall AJ, Mahenthiralingam E, Drevinek P, Kaca W, Drulis-Kawa Z, Stoitsova SR, Toth V, Coenye T, Zlosnik JE, Burns JL, Sá-Correia I, De Vos D, Pirnay JP, Kidd TJ, Reid D, Manos J, Klockgether J, Wiehlmann L, Tümmler B, McClean S, Winstanley C (2013) Developing an international Pseudomonas aeruginosa reference panel. Microbiologyopen 2: 1010-1023.
  • Desai NC, Joshi VV, Rajpara KM, Vaghani HV, Satodiya HM (2013) Microwave-assisted synthesis and antimicrobial screening of new imidazole derivatives bearing 4-thiazolidinone nucleus. Med Chem Res 22: 1893-1908.
  • Gloyne LS, Grant GD, Perkins AV, Powell KL, McDermott CM, Johnson PV, Anderson GJ, Kiefel M, Anoopkumar-Dukie S (2011) Pyocyanin-induced toxicity in A549 respiratory cells is causally linked to oxidative stress. Toxicology in Vitro 25: 1353-1358.
  • Kasprzak KS, Sunderman FW Jr, Salnikow K (2003) Nickel carcinogenesis. Mutat Res 533: 67-97.
  • Khabnadideh S, Rezaei Z, Khalafi-Nezhad A, Bahrinajafi R, Mohamadi R, Farrokhroz AA (2003) Synthesis of N-Alkylated derivatives of imidazole as antibacterial agents. Bioorg Med Chem Lett 13: 2863-2865.
  • Khalafi-Nezhad A, Soltani Rad MN, Mohabatkar H, Asrari Z, Hemmateenejad B (2005) Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives. Bioorg Med Chem 13: 1931-1938.
  • Khan MS, Siddiqui SA, Siddiqui MS, Goswami U, Srinivasan KV, Khan MI (2008) Antibacterial activity of synthesized 2,4,5-trisubstituted imidazole derivatives. Chem Biol Drug Des 72: 197-204.
  • Kolpen M, Kühl M, Bjarnsholt T, Moser C, Hansen CR, Liengaard L, Kharazmi A, Pressler T, Høiby N, Jensen PØ (2014) Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection. PLoS One 9: e84353.
  • Kurdziel K, Głowiak T (2000) X-ray and spectroscopic characterisation of octahedral cobalt(II) and nickel(II) complexes with 1-allylimidazole in the solid state and electron-donor properties of the latter in aqueous solution. Polyhedron 19: 2183-2188.
  • Managò A, Becker KA, Carpinteiro A, Wilker B, Soddemann M, Seitz AP, Edwards MJ, Grassmé H, Szabò I, Gulbins E (2015) Pseudomonas aeruginosa pyocyanin induces neutrophil death via mitochondrial reactive oxygen species and mitochondrial acid sphingomyelinase. Antioxid Redox Signal 22: 1097-1110.
  • Meyer JM, Neely A, Stintzi A, Georges C, Holder IA (1996) Pyoverdin is essential for virulence of Pseudomonas aeruginosa. Infect Immun 64: 518-523.
  • Muller M, Merrett ND (2015) Mechanism for glutathione-mediated protection against the Pseudomonas aeruginosa redox toxin, pyocyanin. Chem Biol Interact 232: 30-37.
  • Nadal Jimenez P, Koch G, Papaioannou E, Wahjudi M, Krzeslak J, Coenye T, Cool RH, Quax WJ (2010) Role of PvdQ in Pseudomonas aeruginosa virulence under iron-limiting conditions. Microbiology 156: 49-59.
  • Nguyen AT, O'Neill MJ, Watts AM, Robson CL, Lamont IL, Wilks A, Oglesby-Sherrouse AG (2014) Adaptation of iron homeostasis pathways by a Pseudomonas aeruginosa pyoverdine mutant in the cystic fibrosis lung. J Bacteriol 196: 2265-2276.
  • Sekhon BS (2010) Metalloantibiotics and antibiotic mimics - an overview. J Pharm Educ Res 1: 1-20.
  • Sharma D, Narasimhan B, Kumar P, Judge V, Narang R, De Clercq E, Balzarini J (2009) Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. Eur J Med Chem 44: 2347-2353.
  • Simonetti G, Baffa S, Simonetti GN (2001) Contact imidazole activity against resistant bacteria and fungi. Int J Antimicrob Agents 17: 389-393.
  • Slezak A, Dworecki K, Slezak IH, Wasik S (2005) Permeability coefficient model equations of the complex: Membrane-concentration boundary layers for ternary nonelectrolyte solutions. J Memb Sci 267: 50-57.
  • Stewart PS, Costerton JW (2001) Antibiotic resistance of bacteria in biofilms. Lancet 358: 135-138.
  • Wilson R, Sykes DA, Watson D, Rutman A, Taylor GW, Cole PJ (1988) Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium. Infect Immun 56: 2515-1517.
  • Vijesh AM, Isloor AM, Telkar S, Peethambar SK, Rai S, Isloor N (2011) Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. Eur J Med Chem 46: 3531-3536.
  • Vijesh AM, Isloor AM, Telkar S, Arulmoli T, Fun H-K (2013) Molecular docking studies of some new imidazole derivatives for antimicrobial properties. Arabian Journal of Chemistry 6: 197-204.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv62p739kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.