Preferences help
enabled [disable] Abstract
Number of results
2015 | 62 | 4 | 633-640
Article title

Immune response gene polymorphisms in tuberculosis

Title variants
Languages of publication
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (M.tb), remains a leading public health problem in most parts of the world. Despite the discovery of the bacilli over 100 years ago, there are still many unanswered questions about the host resistance to TB. Although one third of the world's population is infected with virulent M.tb, no more than 5-10% develop active disease within their lifetime. A lot of studies suggest that host genetic factors determine the outcome of M.tb-host interactions, however, specific genes and polymorphisms that govern the development of TB are not completely understood. Strong evidence exists for genes encoding pattern recognition receptors (TLR, CD14), C-type lectins, cytokines/chemokines and their receptors (IFN-γ, TNF-α, IL-12, IL-10, MCP-1, MMP-1), major histocompatibility complex (MHC) molecules, vitamin D receptor (VDR), and proton-coupled divalent metal ion transporters (SLC11A1). Polymorphisms in these genes have a diverse influence on the susceptibility to or protection against TB among particular families, ethnicities and races. In this paper, we review recent discoveries in genetic studies and correlate these findings with their influence on TB susceptibility.
Physical description
  • Division of Cellular Immunology, Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Łódź, Poland
  • Division of Cellular Immunology, Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Łódź, Poland
  • Division of Cellular Immunology, Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Łódź, Poland
  • Division of Cellular Immunology, Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Łódź, Poland
  • Division of Cellular Immunology, Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Łódź, Poland
  • Akahoshi M, Nakashima H, Miyake K, Inoue Y, Shimizu S, Tanaka Y, Okada K, Otsuka T, Harada M (2003) Influence of interleukin-12 receptor beta1 polymorphisms on tuberculosis. Hum Genet 112: 237-243.
  • Alter A, de Leseleuc L, Van Thuc N, Thai VH, Huong NT, Ba NN, Cardoso CC, Grant AV, Abel L, Moraes MO, Alcais A, Schurr E (2010) Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. Hum Genet 127: 337-348.
  • Arji N, Busson M, Iraqi G, Bourkadi JE, Benjouad A, Bouayad A, Mariaselvam C, Salah S, Fortier C, Amokrane K, Marzais F, Boukouaci W, Krishnamoorthy R, Charron D, El Aouad R, Tamouza R (2014) Genetic diversity of TLR2, TLR4, and VDR loci and pulmonary tuberculosis in Moroccan patients. J Infect Dev Ctries 8: 430-440.
  • Barreiro LB, Neyrolles O, Babb CL, Tailleux L, Quach H, McElreavey K, Helden PD, Hoal EG, Gicquel B, Quintana-Murci L (2006) Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. PLoS Med 3: e20.
  • Bedford PA, Burke F, Stagg AJ, Knight SC (2008) Dendritic cells derived from bone marrow cells fail to acquire and present major histocompatibility complex antigens from other dendritic cells. Immunology 124: 542-552.
  • Bellamy R, Ruwende C, Corrah T, McAdam KP, Whittle C, Hill AV (1998) Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N Engl J Med 338: 640-644.
  • Bellamy R, Ruwende C, Corrah T, McAdam KP, Thursz M, Whittle HC, Hill AV (1999) Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene. J Infect Dis 179: 721-724.
  • Ben-Ali M, Barbouche MR, Bousnina S, Chabbou A, Dellagi K (2004) Toll-like receptor 2 Arg677Trp polymorphisms is associated with susceptibility to tuberculosis in Tunisian patients. Clin Diagn Lab Immunol 11: 625-626.
  • Ben-Ali M, Barreiro LB, Chabbou A, Haltiti R, Braham E, Neyrolles O, Dellagi K, Gicquel B, Quintana-Murci L, Barbouche MR (2007) Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients. Hum Immunol 68: 908-912.
  • Berrington WR, Hawn TR (2007) Mycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter? Immunol Rev 219: 167-186.
  • Boily-Larouche G, Zijenah LS, Mbizvo M, Ward BJ, Roger M (2007) DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibility. Hum Immunol 68: 523-530.
  • Bornman L, Campbell SJ, Fielding K, Bah B, Sillah J, Gustafson P, Manneh K, Lisse I, Allen A, Sirugo G, Sylla A, Aaby P, McAdam KP, Bah-Sow O, Bennett S, Lienhardt C, Hill AV (2004) Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. J Infect Dis 190: 1631-41.
  • Bothamley GH, Beck JS, Schreuder GM, D'Amaro J, de Vries RR, Kardjito T, Ivanyi J (1989) Association of tuberculosis and M. tuberculosis-specific antibody levels with HLA. J Infect Dis 159: 549-555.
  • Brahmajothi V, Pitchappan RM, Kakkanaiah VN, Sashidhar M, Rajaram K, Ramu S, Palanimurugan K, Paramasivan CN, Prabhakar R (1991) Association of pulmonary tuberculosis and HLA in south India. Tubercle 72: 123-132.
  • Casanova JL, Abel L (2004) The human model: a genetic dissection of immunity to infection in natural conditions. Nat Rev Immunol 4: 55-66.
  • Cooke GS, Hill AV (2001) Genetics of susceptibility to human infectious disease. Nat Rev Genet 2: 967-977.
  • Cooke GS, Campbell SJ, Sillah J, Gustafson P, Bah B, Sirugo G, Bennett S, McAdam KP, Sow O, Lienhardt C, Hill AV (2006) Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis. Am J Respir Crit Care Med 174: 339-343.
  • Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM (1993) Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178: 2243-2247.
  • Cooper AM, Magram J, Ferrante J, Orme IM (1997) Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 186: 39-45.
  • Correa PA, Gomez LM, Cadena J, Anaya JM (2005) Autoimmunity and tuberculosis. Opposite association with TNF polymorphism. J Rheumatol 32: 219-224.
  • Delgado JC, Baena A, Thim S, Goldfeld AE (2002) Ethnic-specific genetic associations with pulmonary tuberculosis. J Infect Dis 186: 1463-1468.
  • Denholm JT, McBryde ES, Eisen DP (2010) Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis. Clin Exp Immunol 162: 84-90.
  • Druszczyńska M, Strapagiel D, Kwiatkowska S, Kowalewicz-Kulbat M, Rózalska B, Chmiela M, Rudnicka W (2006) Tuberculosis bacilli still posing a threat. Polymorphism of genes regulating anti-mycobacterial properties of macrophages. Pol J Microbiol 55: 7-12.
  • Ehlers S (2010) DC-SIGN and mannosylated surface structures of Mycobacterium tuberculosis: a deceptive liaison. Eur J Cell Biol 89: 95-101.
  • El Sahly HM, Reich RA, Dou SJ, Musser JM, Graviss EA (2004) The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups. Scand J Infect Dis 36: 106-108.
  • Ferguson JS, Schlesinger LS (2000) Pulmonary surfactant in innate immunity and the pathogenesis of tuberculosis. Tuber Lung Dis 80: 173-184.
  • Flores-Villanueva PO, Ruiz-Morales JA, Song CH, Flores LM, Jo EK, Montano M, Barnes PF, Selman M, Granados J (2005) A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. J Exp Med 202: 1649-1658.
  • Floros J, Lin HM, Garcia A, Salazar MA, Guo X, DiAngelo S, Montano M, Luo J, Pardo A, Selman M (2000) Surfactant protein genetic marker alleles identify a subgroup of tuberculosis in a Mexican population. J Infect Dis 182: 1473-1478.
  • Fraser DA, Bulat-Kardum L, Knezevic J, Babarovic P, Matakovic-Mileusnic N, Dellacasagrande J, Matanic D, Pavelic J, Beg-Zec Z, Dembic Z (2003) Interferon-gamma receptor-1 gene polymorphism in tuberculosis patients from Croatia. Scand J Immunol 57: 480-484.
  • Freidin MB, Rudko AA, Kolokolova OV, Strelis AK, Puzyrev VP (2006) Association between the 1188 A/C polymorphism in the human IL12B gene and Th1-mediated infectious diseases. Int J Immunogenet 33: 231-232.
  • Ganachari MM, Ruiz-Morales JA, Gomez de la Torre Pretell JC, Dinh J, Granados J, Flores-Villanueva PO (2010) Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG vaccinated individuals. Plos ONE 5: e8881.
  • Ganachari M, Guio H, Zhao N, Flores-Villanueva PO (2012) Host gene-encoded severe lung TB: from genes to the potential pathways. Genes Immun 13: 605-620. Http://
  • Gao PS, Fujishima S, Mao XQ, Remus N, Kanda M, Enomoto T, Dake Y, Bottini N, Tabuchi M, Hasegawa N, Yamaguchi K, Tiemessen C, Hopkin JM, Shirakawa T, Kishi F (2000) Genetic variants of NRAMP1 and active tuberculosis in Japanese populations. International tuberculosis genetics team. Clin Genet 58: 74-76.
  • Goldfeld AE, Delgado JC, Thim S, Bozon MV, Uglialoro AM, Turbay D, Cohen C, Yunis EJ (1998) Association of an HLA-DQ allele with clinical tuberculosis. JAMA 279: 226-228.
  • Goldfeld AE (2004) Genetic susceptibility to pulmonary tuberculosis in Cambodia. Tuberculosis 84: 76-81.
  • Gomez LM, Anaya JM, Sierra-Filardi E, Cadena J, Corbi A, Martin J (2006) Analysis of DC-SIGN (CD209) functional variants in patients with tuberculosis. Hum Immunol 67: 808-811.
  • Kang YA, Lee HW, Kim YW, Han SK, Shim YS, Yim JJ (2009) Association between the -159C/T CD14 gene polymorphism and tuberculosis in a Korean population. FEMS Immunol Med Microbiol 57: 229-235.
  • Kasperkiewicz K, Swierzko A, Bartlomiejczyk MA, Cedzynski M, Noszczynska M, Duda KA, Michalski M, Skurnik M (2015) Interaction of human mannose-binding lectin (MBL) with Yersinia enterocolitica lipopolysaccharide. Int J Med Microbiol 305: 544-552.
  • Kaufmann SH (2013) Tuberculosis vaccines: Time to think about the next generation. Seminars in Immunology 25: 172-181.
  • Kettaneh A, Seng L, Tiev KP, Toledano C, Fabre B, Cabane J (2006) Human leukocyte antigens and susceptibility to tuberculosis: a meta-analysis of case-control studies. Int J Tuberc Lung Dis 10: 717-725.
  • LeBouder E, Rey-Nores JE, Rushmere NK, Grigorov M, Lawn SD, Affolter M, Griffin GE, Ferrara P, Schiffrin EJ, Morgan BP, Labeta MO (2003) Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk. J Immunol 171: 6680-6689.
  • Lee HW, Lee HS, Kim DK, Ko DS, Han SK, Shim YS, Yim JJ (2005) Lack of an association between interleukin-12 receptor beta1 polymorphisms and tuberculosis in Koreans. Respiration 72: 365-368.
  • Lee HK, Dunzendorfer S, Soldau K, Tobias PS (2006) Double-stranded RNA-mediated TLR3 activation is enhanced by CD14. Immunity 24: 153-163.
  • Lee KH, Wucherpfennig KW, Wiley DC (2001) Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol 2: 501-507.
  • LeVan TD, Bloom JW, Bailey TJ, Karp CL, Halonen M, Martinez FD, Vercelli D (2001) A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 167: 5838-5844.
  • Lio D, Marino V, Serauto A, Gioia V, Scola L, Crivello A, Forte GI, Colonna-Romano G, Candore G, Caruso C (2002) Genotype frequencies of the +874T/A single nucleotide polymorphism in the first intron of interferon-gamma gene in a sample of Sicilian patients affected by tuberculosis. Eur J Immunogenet 29: 371-374.
  • Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311: 1770-1773.
  • Lopez-Maderuelo D, Arnalich F, Serantes R, Gonzalez A, Codoceo R, Madero R, Vazquez JJ, Montiel C (2003) Interferon-gamma and interleukin-10 gene polymorphisms in pulmonary tuberculosis. Am J Respir Crit Care Med 167: 970-975.
  • Ma X, Dou S, Wright JA, Reich RA, Teeter LD, El Sahly HM, Awe RJ, Musser JM, Graviss EA (2002) 5' dinucleotide repeat polymorphism of NRAMP1 and susceptibility to tuberculosis among Caucasian patients in Houston, Texas. Int J Tuberc Lung Dis 6: 818-823.
  • Madan T, Saxena S, Murthy KJ, Muralidhar K, Sarma PU (2002) Association of polymorphisms in the collagen region of human SP-A1 and SP-A2 genes with pulmonary tuberculosis in Indian population. Clin Chem Lab Med 40: 1002-1008.
  • Malik S, Greenwood CM, Eguale T, Kifle A, Beyene J, Habte A, Tadesse A, Gebrexabher H, Britton S, Schurr E (2006) Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia. Hum Genet 118: 752-759.
  • Mao X, Liu S, Tang B, Wang J, Huang H, Chen S (2015) IL-1β+3953C/T, -511T/C and IL-6 -174C/G polymorphisms in association with tuberculosis susceptibility: a meta-analysis. Gene 573: 75-83.
  • Miao R, Li J, Sun Z, Xu F, Shen H (2011) Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility. Tuberculosis 91: 268-272.
  • Moller M, Hoal EG (2010) Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. Tuberculosis 90: 71-83.
  • Morahan G, Kaur G, Singh M, Rapthap CC, Kumar N, Katoch K, Mehra NK, Huang D (2007) Association of variants in the IL12B gene with leprosy and tuberculosis. Tissue Antigens 69 (Suppl 1): 234-236.
  • Noguchi E, Yokouchi Y, Shibasaki M, Kamioka M, Yamakawa-Kobayashi K, Matsui A, Arinami T (2001) Identification of missense mutation in the IL12B gene: lack of association between IL12B polymorphisms and asthma and allergic rhinitis in the Japanese population. Genes Immun 2: 401-403.
  • Ogus AC, Yoldas B, Ozdemir T, Uguz A, Olcen S, Keser I, Coskun M, Cilli A, Yegin O (2004) The Arg753Gln polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 23: 219-223.
  • Oral HB, Budak F, Uzaslan EK, Basturk B, Bekar A, Akalin H, Ege E, Ener B, Goral G (2006) Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis. Cytokine 35: 143-147.
  • Pacheco E, Fonseca C, Montes C, Zabaleta J, Garcia LF, Arias MA (2004) CD14 gene promoter polymorphism in different clinical forms of tuberculosis. FEMS Immunol Med Microbiol 40: 207-213.
  • Rajaram MV, Brooks MN, Morris JD, Torrelles JB, Azad AK, Schlesinger LS (2010) Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor gamma linking mannose receptor recognition to regulation of immune responses. J Immunol 185: 929-942.
  • Reiling N, Holscher C, Fehrenbach A, Kroger S, Kirschning CJ, Goyert S, Ehler S (2002) Cutting edge: Toll-like receptor (TLR)-2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol 169: 3480-3484.
  • Remus N, El Baghdadi J, Fieschi C, Feinberg J, Quintin T, Chentoufi M, Schurr E, Benslimane A, Casanova JL, Abel L (2004) Association of IL12RB1 polymorphisms with pulmonary tuberculosis in adults in Morocco. J Infect Dis 190: 580-587.
  • Rosas-Taraco AG, Revol A, Salinas-Carmona MC, Rendon A, Caballero-Olin G, Arce-Mendoza AY (2007) CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. J Infect Dis 196: 1698-1706.
  • Rossouw M, Nel HJ, Cooke GS, van Helden PD, Hoal EG (2003) Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene. Lancet 361: 1871-1872.
  • Ryu S, Park YK, Bai GH, Kim SJ, Park SN, Kang S (2000) 3'UTR polymorphisms in the NRAMP1 gene are associated with susceptibility to tuberculosis in Koreans. Int J Tuberc Lung Dis 4: 577-580.
  • Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, Mahmood F (2013) Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis. BMC Infect Dis 13: 22.
  • Salie M, Daya M, Lucas LA, Warren RM, van der Spuy GD, van Helden PD, Hoal EG, Moller M (2015) Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms. Infect Genet Evol 34: 221-229.
  • Schäfer G, Jacobs M, Wilkinson RJ, Brown GD (2009) Non-opsonic recognition of Mycobacterium tuberculosis by phagocytes. J Innate Immun 1: 231-243.
  • Scola L, Crivello A, Marino V, Gioia V, Serauto A, Candore G, Colonna-Romano G, Caruso C, Lio D (2003) IL-10 and TNF-alpha polymorphisms in a sample of Sicilian patients affected by tuberculosis: implication for ageing and life span expectancy. Mech Ageing Dev 124: 569-572.
  • Scorza M, Liguori R, Elce A, Salvatore F, Castaldo G (2015) Biological role of mannose binding lectin: From newborns to centenarians. Clin Chim Acta S0009-8981(15)00139-4.
  • Selvaraj P, Alagarasu K, Harishankar M, Vidyarani M, Nisha Rajeswari D, Narayanan PR (2008) Cytokine gene polymorphisms and cytokine levels in pulmonary tuberculosis. Cytokine 43: 26-33.
  • Sharma S, Rathored J, Ghosh B, Sharma SS (2010) Genetic polymorphisms in TNF genes and tuberculosis in North Indians. BMC Infect Dis 10: 165.
  • Shin HD, Park BL, Kim YH, Cheong HS, Lee IH, Park SK (2005) Common interleukin 10 polymorphism associated with decreased risk of tuberculosis. Exp Mol Med 37: 128-132.
  • Singla N, Gupta D, Joshi A, Batra N, Singh J, Birbian N (2012) Association of mannose-binding lectin gene polymorphism with tuberculosis susceptibility and sputum conversion time. Int J Immunogenet 39: 10-14.
  • Soborg C, Madsen HO, Andersen AB, Lillebaek T, Kok-Jensen A, Garred P (2003) Mannose-binding lectin polymorphisms in clinical tuberculosis. J Infect Dis 188: 777-782.
  • Soborg C, Andersen AB, Range N, Malenganisho W, Friis H, Magnussen P, Temu MM, Changalucha J, Madsen HO, Garred P (2007) Influence of candidate susceptibility genes on tuberculosis in a high endemic region. Mol Immunol 44: 2213-2220.
  • Sorensen GL, Husby S, Holmskov U (2007) Surfactant protein A and surfactant protein D variation in pulmonary disease. Immunobiology 212: 381-416.
  • Stein CM, Zalwango S, Chiunda AB, Millard C, Leontiev DV, Horvath AL, Cartier KC, Chervenak K, Boom WH, Elston RC, Mugerwa RD, Whalen CC, Iyengar SK (2007) Linkage and association analysis of candidate genes for TB and TNF-alpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes. Hum Genet 121: 663-673.
  • Sun YP, Cai QS (2015) Vitamin D receptor FokI gene polymorphism and tuberculosis susceptibility: a meta-analysis. Genet Mol Res 14: 6156-6163.
  • Tailleux L, Pham-Thi N, Bergeron-Lafaurie A, Herrmann JL, Charles P, Schwartz O, Scheinmann P, Lagrange PH, de Blic J, Tazi A, Gicquel B, Neyrolles O (2005) DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis. PLoS Med 2: e381.
  • Thuong NT, Hawn TR, Thwaites GE, Chau TT, Lan NT, Quy HT, Hieu NT, Aderem A, Hien TT, Farrar JJ, Dunstan SJ (2007) A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis. Genes Immun 8: 422-428.
  • Thuong NT, Dunstan SJ, Chau TT, Thorsson V, Simmons CP, Quyen NT, Thwaites GE, Thi Ngoc Lan N, Hibberd M, Teo YY, Seielstad M, Aderem A, Farrar JJ, Hawn TR (2008) Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLOS Pathogens 4: e1000229.
  • Tong X, Chen L, Liu S, Yan Z, Peng S, Zhang Y, Fan H (2015) Polymorphisms in HLA-DRB1 gene and the risk of tuberculosis: a meta-analysis of 31 studies. Lung 193: 309-318.
  • Tso HW, Lau YL, Tam CM, Wong HS, Chiang AK (2004) Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population. J Infect Dis 190: 913-919.
  • Turner J, Gonzalez-Juarrero M, Ellis DL, Basaraba RJ, Kipnis A, Orme IM, Cooper AM (2002) In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. J Immunol 169: 6343-6351.
  • Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004) Genetics and biology of vitamin D receptor polymorphisms. Gene 338: 143-156.
  • Vannberg FO, Chapman SJ, Khor CC, Tosh K, Floyd S, Jackson-Sillah D, Crampin A, Sichali L, Bah B, Gustafson P, Aaby P, McAdam KP, Bah-Sow O, Lienhardt C, Sirugo G, Fine P, Hill AV (2008) CD209 genetic polymorphism and tuberculosis disease. PLoS One 3: e1388.
  • Velez DR, Wejse C, Stryjewski ME, Abbate E, Hulme WF, Myers JL, Estevan R, Patillo SG, Olesen R, Tacconelli A, Sirugo G, Gilbert JR, Hamilton CD, Scott WK (2010) Variants in Toll-like receptors 2 and 9 influence susceptibility to pulomary tuberculosis in Caucasians, African-Americans, and West Africans. Hum Genet 127: 65-73.
  • World Health [Internet]. Global Tuberculosis Report 2014. Available from:
  • Wu H, Yang L (2015) Arg753Gln polymorphisms in Toll-like receptor 2 gene are associated with tuberculosis risk: a meta-analysis. Med Sci Monit 21: 2196-2202.
  • Yim JJ, Lee HW, Lee HS, Kim YW, Han SK, Shim YS, Holland SM (2006) The association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and tuberculosis among Koreans. Genes Immun 7: 150-155.
  • Yim JJ, Selvaraj P (2010) Genetic susceptibility in tuberculosis. Respirology 15: 241-256.
  • Yuan Q, Chen H, Zheng X, Chen X, Li Q, Zhang Y, Zhang X, Shi T, Zhou J, Chen Q, Yu S (2014) The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis. Mol Biol Rep 41: 7623-7629.
  • Zhang X, Li X, Zhang W, Wei L, Jiang T, Chen Z, Meng C, Liu J, Wu F, Wang C, Li F, Sun X, Li Z, Li JC (2013) The novel human MRC1 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis in Chinese Uygurand Kazak populations. Mol Biol Rep 40: 5073-5083.
  • Zheng R, Zhou Y, Qin L, Jin R, Wang J, Lu J, Wang W, Tang S, Hu Z (2011) Relationship between polymorphism of DC-SIGN (CD209) gene and susceptibility to pulmonary tuberculosis in an eastern Chinese population. Hum Immunol 72: 183-186.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.