Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies

• Authors: Paulina Koczurkiewicz , Jarosław Czyż , Irma Podolak , Katarzyna Wójcik , Agnieszka Galanty , Zbigniew Janeczko , Marta Michalik
• Languages of publication: EN

Abstracts

EN

Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentrations (more than 100 µM) saponins exert cytotoxic and haemolytic effects via permeabilization of the cell membranes. Noteworthy, the inhibition of cancer cell proliferation, the induction of apoptosis and attenuation of cell invasiveness is observed in the presence of low saponin concentrations. Saponins might affect the expression of genes associated with malignancy. These alterations are directly related to the invasive phenotype of cancer cells and depend on "cellular context". It illustrates the relationships between the action of saponins, and the momentary genomic/proteomic status of cancer cells. Here, we discuss the hallmarks of anti-cancer activity of saponins with the particular emphasis on anti-invasive effect of diverse groups of saponins that have been investigated in relation to tumor therapy.

Keywords

EN

triterpene saponins; cancer cells; invasiveness; apoptosis; proliferation

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2015
• Volume: 62
• Issue: 3
• Pages: 383-393

Dates

published

2015

received

2015-05-26

revised

2015-06-21

accepted

2015-07-17

(unknown)

2015-08-26

Contributors

author

Paulina Koczurkiewicz

• Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland
• Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland

author

Jarosław Czyż

• Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland

author

Irma Podolak

• Department of Pharmacognosy, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland

author

Katarzyna Wójcik

• Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland
• Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland

author

Agnieszka Galanty

• Department of Pharmacognosy, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland

author

Zbigniew Janeczko

• Department of Pharmacognosy, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland

author

Marta Michalik

• Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland

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Identifiers

DOI

10.18388/abp.2015_1089