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2015 | 62 | 2 | 229-233
Article title

Study of O/W micro- and nano-emulsions based on propylene glycol diester as a vehicle for geranic acid

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Nano- and microemulsions containing as the oil phase caprylic/capric propylene glycol diesters (Crodamol PC) were investigated as potential vehicle for controlled release of geranic acid. The influence of emulsifiers and co-surfactants on stability of the emulsions was investigated. Different kind of polysorbates (ethoxylated esters of sorbitan and fatty acids) were applied as the emulsifiers. The short-chain alcohols (ethanol, 1-propanol, 1-butanol) were used as co-surfactants. The emulsions were prepared at ambient temperature (25°C), by the phase inversion composition method (PIC). The stable O/W high dispersed emulsion systems based on Crodamol PC, of mean droplets size less than 200 nm, were prepared. Microemulsions stabilized by the mixture of Polisorbat 80 and 1-butanol were characterized by the largest degree of dispersion (137 nm) and the lowest PDI value (0.094), at surfactant/co-surfactant: oil weight ratio 90:10. The stable nano-emulsion (mean droplet size of 33 nm) was obtained for surfactant: oil (S:O) weight ratio 90:10, without co-surfactant addition. This nano-emulsion was chosen to release studies. The obtained results showed that the prepared stable nano-emulsion can be used as a carrier for controlled release of geranic acid. The active substance release from the nano-emulsion and the oil solution, after 24 hours was 22%.
Physical description
  • Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland
  • Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland
  • Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland
  • Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland
  • Anton N, Vandamme TF (2011) Nano-emulsions and micro-emulsions: Clarifications of the critical differences. Pharm Res 28: 978-985.
  • Bouchemal K, Briancon S, Perrier E, Fessi H (2004) Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimization. Int J Pharm 280: 241-251.
  • Choi SY (2012) Inhibitory effects of geranic acid derivatives on melanin biosynthesis. J Cosmet Sci 63: 351-358.
  • El Maghraby GM (2008) Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of co-surfactants. Int J Pharm 355: 285-292.
  • Fernandez P, Andre V, Rieger J, Kühnle A (2004) Nano-emulsion formation by emulsion phase inversion. Colloids Surf 251: 53-58.
  • Gaonkar AG, Bagwe RP (2003) Microemulsions in Foods: Challenges and Aplications in Adsorption and aggregation of surfactants in solution, Mittal KL, Shah DO eds, pp 407-409. Marcel Dekker New York USA.
  • Information materials of dr-Straetmans Company,
  • McClements DJ (2012) Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter 8: 1719-1729.
  • Patel D, Li P, Serajuddin A (2012) Enhanced microemulsion formation in lipid-based drug delivery systems by combining mono-esters of medium-chain fatty acids with di- or tri-esters. J Excip Food Chem 3: 29-44.
  • Peltola S, Saarinen-Savolainen P, Kiesvaara J, Suhonen TM, Urtti A (2003) Microemulsions for topical delivery of estradiol. Int J Pharm 254: 99-107.
  • Rhee YS, Choi JG, Park ES, Chi SC (2001) Transdermal delivery of ketoprofen using microemulsions. Int J Pharm 228: 161-170.
  • Sadurni N, Solans C, Azemar N, Garcia-Celma MJ (2005) Studies on the formation of O/W nano-emulsions, by low-energy emulsification methods, suitable for pharmaceutical applications. Eur J Pharm Sci 26: 438-445.
  • Shafiq-un-Nabi S, Shakeel F, Talegaonkar S, Ali J, Baboota S, Ahuja A, Khar RK, Ali M (2007) Formulation development and optimization using nanoemulsion technique: a technical note. AAPS PharmSciTech 8: E1-E6.
  • Shevachman M, Shani A, Garti N (2004) Formation and investigation of microemulsions based on jojoba oil and nonionic surfactants. J Am Oil Chem Soc 81: 1143-1152.
  • Wais M, Samad A, Khale A, Aqil M, Khan M, (2012) Investigation of nanoemulsion system for transdermal delivery of glibenclamide. Int J Pharm Pharm Sci 4: 482.
  • Warisnoicharoen W, Lansley AB, Lawrence MJ (2000) Nonionic oil-in-water microemulsions: the effect of oil type on phase behavior. Int J Pharm 198: 7-27.
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