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2015 | 62 | 2 | 207-213
Article title

Protective effects of quercetin on cadmium fluoride induced oxidative stress at different intervals of time in mouse liver

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EN
Abstracts
EN
Quercetin, a member of the flavonoid family is a major antioxidant acquired in humans by food consumption, while Cadmium fluoride (CdF2) is one of the naturally occurring chemicals having adverse effects. The protective effect of quercetin on time dependent oxidative damage induced in mice liver by CdF2 was studied in the following groups of mice consisting of six mice each: (i) control group; (ii) mice treated with single i.p injection of 2 mg/kg bw CdF2 for 24 h; (iii) mice treated with single i.p injection of 2 mg/kg bw CdF2 for 48 h; (iv) mice treated with single i.p injection of quercetin (100 mg/kg bw); (v) mice treated with i.p injection of 100 mg/kg bw of quercetin followed by i.p injection of CdF2 (2 mg/kg bw) for 24 h; and (vi) mice treated with i.p injection of 100mg/kg bw of quercetin followed by CdF2 (2 mg/kg bw) for 48 h. Administration of quercetin two hours before CdF2 significantly reduced the biochemical alterations in reduced glutathione, ascorbic acid, lipid peroxidation, super oxide dismutase, catalase and total protein (p<0.05). Histopathology also showed the protective effect of quercetin. The livers treated with CdF2 were atrophic, markedly nodular, inflamed and necrotic. However, this effect was reduced to a minimum in the mice pre-treated for two hours with quercetin.
Publisher

Year
Volume
62
Issue
2
Pages
207-213
Physical description
Dates
published
2015
received
2014-09-23
revised
2015-03-01
accepted
2015-03-03
(unknown)
2015-04-09
Contributors
author
  • Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
  • Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
  • Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
author
  • Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv62p207kz
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