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2015 | 62 | 2 | 169-171
Article title

The importance of liver lesions and changes to biochemical and coagulation factors in the pathogenesis of RHD

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EN
Abstracts
EN
RHDV (rabbit haemorrhagic disease virus) is an etiologic factor of RHD (rabbit haemorrhagic disease), which is highly morbid and mortal viral infection of an adult European rabbit. Although three decades have passed since the first outbreak of rabbit haemorrhagic disease, the pathogenesis of RHD has still not been fully elucidated. It is known that RHDV replicates in the liver within the first hours following infection, causing necrotic and apoptotic cell death of hepatocytes. Anatomopathological changes are also observed in other organs of infected rabbits, i.e. lungs, spleen, kidneys, heart, as well as central nerve system. These changes leading to animals death are predominantly caused by systemic hemorrhagic diathesis with disseminated intravascular coagulation (DIC), appearing most likely as a consequence of liver cell loss through RHDV-induced apoptosis. In this paper, we presented previously described changes in biochemical and coagulation factors in RHDV infection.
Publisher

Year
Volume
62
Issue
2
Pages
169-171
Physical description
Dates
published
2015
received
2014-11-25
revised
2015-02-26
accepted
2015-03-08
(unknown)
2015-04-23
Contributors
  • Department of Immunology, Faculty of Biology, University of Szczecin, Szczecin, Poland
  • Department of Immunology, Faculty of Biology, University of Szczecin, Szczecin, Poland
  • Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland
References
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Publication order reference
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bwmeta1.element.bwnjournal-article-abpv62p169kz
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