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2014 | 61 | 4 | 801-807
Article title

Female headstart in resistance to hyperoxia-induced oxidative stress in mice

Content
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EN
Abstracts
EN
Increased oxygen concentration (hyperoxia) induces oxidative damage of tissues and organs. Oxygen toxicity in hyperoxia is controlled by factors such as sex, age, tissue, strain and hormones. In most species females show lower incidence of some age-related pathologies linked with oxidative stress, which has been attributed to a beneficial effect of ovarian hormones. In this study we found that hyperoxia induced hepatic oxidative damage exclusively in male CBA/H mice, followed by their decreased survival. Histopathological examination revealed that the observed differences in survival were not the consequence of acute lung injury induced by hyperoxia. Next, we observed that an increased Sirt1 protein level in hyperoxia-exposed female CBA/H mice correlated with their lower PPAR-γ and higher eNOS and Sod2 protein levels. In males, higher PPAR-γ and lower Sod2 protein levels were associated with unchanged Sirt1 expression. Although these results are of a correlative nature only, they clearly show that females show better survival, increased resistance to hyperoxia and have generally more efficient defense systems, which suggests that their headstart in resistance to hyperoxia could be a consequence of the beneficial effect of ovarian hormones.
Keywords
EN
hyperoxia   sex-related   mice   ROS   Sirt1   PPAR-γ   eNOS   Sod2  
Publisher

Year
Volume
61
Issue
4
Pages
801-807
Physical description
Dates
published
2014
received
2014-05-22
revised
2014-08-01
accepted
2014-09-29
(unknown)
2014-10-29
Contributors
author
  • Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
  • Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
  • Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
  • Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
  • Department of Pathology, Medical School University of Zagreb, and University Hospital, Dubrava, Zagreb, Croatia
  • Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
author
  • Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
author
  • Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv61p801kz
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