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2014 | 61 | 4 | 795-799
Article title

The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide

Content
Title variants
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EN
Abstracts
EN
The protective action of quercetin against the pro-oxidant and apoptotic effect of etoposide was investigated in HL-60 cells with a high level of myeloperoxidase (MPO) activity and in cells treated with MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH). Quercetin significantly protected MPO-rich cells against the pro-oxidative (p<0.05) and apoptotic (p<0.05) effects of etoposide. Pre-treatment with ABAH abolished this protective influence of quercetin on apoptosis induced by etoposide but actually enhanced the action effect of quercetin against etoposide-generated reactive oxygen species (ROS) level by this cytostatic drug. Thus quercetin can protect HL-60 cells against the pro-oxidative activity of etoposide regardless of MPO activity.
Year
Volume
61
Issue
4
Pages
795-799
Physical description
Dates
published
2014
received
2014-05-16
accepted
2014-09-11
revised
2014-09-22
(unknown)
2014-12-11
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv61p795kz
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