Association between polymorphisms in CHRNA3 and PHACTR2 gene and environment and NSCLC risk in Chinese population
Languages of publication
Aims. This study aimed to investigate CHRNA3 (rs8040868) and PHACTR2 (rs9390123) single-nucleotide polymorphisms (SNPs) for association with non-small-cell lung cancer (NSCLC) risk in a Chinese population, and whether the environment affects the genetic polymorphisms. Methods. This case and control study included 500 NSCLC patients and 500 age-matched healthy controls. CHRNA3 (rs8040868) and PHACTR2 (rs9390123) SNPs were genotyped and associated for NSCLC risk by computing the odds ratio and 95% confidence interval from multivariate unconditional logistic regression analyses with adjustment of age. Results. The minor allele frequency (MAF) of CHRNA3 (rs8040868) and PHACTR2 (rs9390123) was 0.350 (C) and 0.397 (C), respectively. The frequencies of genotype and allele in CHRNA3 (rs8040868) and PHACTR2 (rs9390123) were not significantly different between the cases and controls, or between either of the subgroups. Conclusion. Although rs8040868 and rs9390123 SNPs are not associated with NSCLC risk in Chinese population, the results strongly suggest that geographical agents interact with human genetic polymorphism independent of ethnic background.
- Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (2004) Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Proc Natl Acad Sci U S A 101: 7187-7192.
- Chikova A, Bernard HU, Shchepotin IB, Grando SA (2012) New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer. Life Sci 91: 1103-1108.
- Ezzati M, Henley SJ, Lopez AD, Thun MJ (2005) Role of smoking in global and regional cancer epidemiology: current patterns and data needs. Int J Cancer 116: 963-971.
- Ezzati M, Lopez AD (2003) Estimates of global mortality attributable to smoking in 2000. Lancet 362: 847-852.
- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
- Le Marchand L, Derby KS, Murphy SE, Hecht SS, Hatsukami D, Carmella SG, Tiirikainen M, Wang H (2008) Smokers with the CHRNA lung cancerassociated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Res 68: 9137-9140.
- Li Z, Bao S, Xu X, Bao Y, Zhang Y (2012) Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene cluster and NSCLC risk in Chinese population. Transl Oncol 5: 448-452.
- Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG et al (2008) Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst 100: 1326-1330.
- Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA (2008) Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 83: 584-594.
- Pesch B, Kendzia B, Gustavsson P, Jöckel KH, Johnen G, Pohlabeln H et al (2012) Cigarette smoking and lung cancer--relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cance 131: 1210-1219.
- Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA et al (2007) Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 16: 36-49.
- Shiraishi K, Kohno T, Kunitoh H, Watanabe S, Goto K, Nishiwaki Y, Shimada Y, Hirose H, Saito I, Kuchiba A, Yamamoto S, Yokota J (2009) Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. Carcinogenesis 30: 65-70.
- Spitz M, Wu X, Wilkinson A, Wei Q (2006) Cancer of the Lung. Oxford, UK: Oxford University Press.
- Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP et al (2008) A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452: 638-642.
- Wang LE, Gorlova OY, Ying J, Qiao Y, Weng SF, Lee AT, et al (2013) Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer. Cancer Res 73: 256-264.
- Zhang Y, Gu C, Shi H, Zhang A, Kong X, Bao W, Deng D, Ren L, Gu D (2012) Association between C3orf21, TP63 polymorphisms and environment and NSCLC in never-smoking Chinese population. Gene 497: 93-97.
Publication order reference