Discrete dynamic system oriented on the formation of prebiotic dipeptides from Rode's experiment

• Authors: Carlos Polanco , José Samaniego , Thomas Buhse , Jorge Castañón González
• Languages of publication: EN

Abstracts

EN

This work attempts to rationalize the possible prebiotic profile of the first dipeptides of about 4 billion years ago based on a computational discrete dynamic system that uses the final yields of the dipeptides obtained in Rode's experiments of salt-induced peptide formation (Rode et al., 1999, Peptides 20: 773-786). The system built a prebiotic scenario that allowed us to observe that (i) the primordial peptide generation was strongly affected by the abundances of the amino acid monomers, (ii) small variations in the concentration of the monomers have almost no effect on the final distribution pattern of the dipeptides and (iii) the most plausible chemical reaction of prebiotic peptide bond formation can be linked to Rode's hypothesis of a salt-induced scenario. The results of our computational simulations were related to former simulations of the Miller, and Fox & Harada experiments on amino acid monomer and oligomer generation, respectively, offering additional information to our approach.

Keywords

EN

origins of life; biogenesis; dipeptides; salt-induced peptide formation

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 4
• Pages: 717-726

Dates

published

2014

received

2013-11-08

revised

2014-07-12

accepted

2014-10-17

(unknown)

2014-12-16

Contributors

author

Carlos Polanco

• Departamento de Matemáticas, Facultad de Ciencias, Universidad Nacional Autónoma de México, México

author

José Samaniego

• Facultad de Ciencias de la Salud, Universidad Anáhuac, Col. Lomas Anáhuac Huixquilucan Estado de México, México

author

Thomas Buhse

• Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México

author

Jorge Castañón González

• Facultad de Ciencias de la Salud, Universidad Anáhuac, Col. Lomas Anáhuac Huixquilucan Estado de México, México

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