The rules of aging: are they universal? Is the yeast model relevant for gerontology?

• Authors: Tomasz Bilinski , Renata Zadrag-Tecza
• Languages of publication: EN

Abstracts

EN

The success of experimental biology was possible due to the use of model organisms. It is believed that the mechanisms of aging have a universal character and they are conserved in a wide range of organisms. The explanation of these universal mechanisms by tracing survival curves of model organisms clearly suggests that death of individuals is a direct consequence of aging. Furthermore, the use of unicellular organisms like yeast Saccharomyces cerevisiae to explain the aging processes of multicellular organisms runs the risk of oversimplification. Aging is a very complex process and therefore in this paper we present arguments suggesting that some of these fundamental assumptions require a deep rethinking and verification.

Keywords

EN

aging; age related diseases; longevity; yeast

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 4
• Pages: 663-669

Dates

published

2014

received

2014-05-28

revised

2014-10-15

accepted

2014-10-27

(unknown)

2014-12-11

Contributors

author

Tomasz Bilinski

• Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszów, Poland

author

Renata Zadrag-Tecza

• Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszów, Poland

References

• Aubert G, Lansdorp PM (2008) Telomeres and aging. Physiol Rev 88: 557-579.
• Banta LM, Robinson JS, Klionsky DJ, Emr SD (1988) Organelle assembly in yeast - characterization of yeast mutants defective in vacuolar biogenesis and protein sorting. J Cell Biol 107: 1369-1383.
• Barbieri M, Bonafe M, Franceschi C, Paolisso G (2003) Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. AM J Physiol-Endoc M 285: E1064-E1071.
• Berlett BS, Stadtman ER (1997) Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272: 20313-20316.
• Bilinski T (2012) Hypertrophy, replicative ageing and the ageing process. FEMS Yeast Res 12: 739-40.
• Bilinski T, Bartosz G (2006) Hypothesis: cell volume limits cell divisions. Acta Biochim Pol 53: 833-835.
• Bilinski T, Zadrag-Tecza R, Bartosz G (2012) Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast. FEMS Yeast Res 12: 97-101.
• Blagosklonny MV (2006) Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 5: 2087-2102.
• Blagosklonny MV (2012) Answering the ultimate question 'What is the Proximal Cause of Aging?'. Aging 4: 861-877.
• Blagosklonny MV (2013) Aging is not programmed Genetic pseudo-program is a shadow of developmental growth. Cell Cycle 12: 3736-3742.
• Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ (2012) Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. BBA-Mol Basis Dis 1822: 753-783.
• Campisi J (2001) From cells to organisms: can we learn about aging from cells in culture? Exp Gerontol 36: 607-618.
• Cohn M, Blackburn EH (1995) Telomerase in yeast. Science 269: 396-400.
• Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J (2008) Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor. Plos Biology 6: 2853-2868.
• De Mesquita DS, Shaw J, Grimbergen JA, Buys MA, Dewi L, Woldringh CL (1997) Vacuole segregation in the Saccharomyces cerevisiae vac2-1 mutant: Structural and biochemical quantification of the segregation defect and formation of new vacuoles. Yeast 13: 999-1008.
• Donaldson MS (2011) A Carotenoid Health Index Based on Plasma Carotenoids and Health Outcomes. Nutrients 3: 1003-1022.
• Egilmez NK, Jazwinski SM (1989) Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae. J Bacteriol 171: 37-42.
• Esterbauer H, Schaur RJ, Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11: 81-128.
• Finch CE, Pike MC, Witten M (1990) Slow mortality rate accelerations during aging in some animals approximate that of humans. Science 249: 902-905.
• Fontana L, Partridge L, Longo VD (2010) Extending Healthy Life Span From Yeast to Humans. Science 328: 321-326.
• Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN (1990) Oxidative damage to DNA during aging - 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87: 4533-4537.
• Ganley AR, Breitenbach M, Kennedy BK, Kobayashi T (2012) Yeast hypertrophy: cause or consequence of aging? Reply to Bilinski et al. FEMS Yeast Res 12: 267-268.
• Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, Kenyon C (2002) Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation. Genetics 161: 1101-1112.
• Guerra-Assuncao JA, Enright AJ (2010) MapMi: automated mapping of microRNA loci. BMC Bioinformatics 11: 133.
• Harman D (1956) Aging: a theory based on free-radical and radiation-chemistry. Journals of Gerontology 11: 298-300.
• Hartwell LH, Unger MW (1977) Unequal division in Saccharomyces cerevisiae and its implications for control of cell division. J Cell Biol 75: 422-435.
• Kaeberlein M (2010) Lessons on longevity from budding yeast. Nature 464: 513-519.
• Kaeberlein M (2012) Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al. FEMS Yeast Res 12: 269-270.
• Kaeberlein M, Burtner CR, Kennedy BK (2007) Recent developments in yeast aging. PLoS Genet 3: 655-660.
• Kaeberlein M, Kirkland KT, Fields S, Kennedy BK (2005a) Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev 126: 491-504.
• Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK (2005b) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310: 1193-1196.
• Kennedy BK, Austriaco NR, Guarente L (1994) Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life-span. J Cell Biol 127: 1985-1993.
• Kimura N, Mikami K, Endoh H (2004) Delayed degradation of parental macronuclear DNA in programmed nuclear death of Paramecium caudatum. Genesis 40: 15-21.
• Kirkwood TB (1977) Evolution of ageing. Nature 270: 301-304.
• Klass MR (1977) Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech Ageing Dev 6: 413-429.
• Klionsky DJ, Herman PK, Emr SD (1990) The fungal vacuole: composition, function, and biogenesis. Microbiol Rev 54: 266-292.
• Lane N (2002) Oxygen: The molecule that Made the World. Oxford University Press.
• Li LT, Chen OS, Ward DM, Kaplan J (2001) CCC1 is a transporter that mediates vacuolar iron storage in yeast. J Biol Chem 276: 29515-29519.
• Minois N, Frajnt M, Wilson C, Vaupel JW (2005) Advances in measuring lifespan in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA 102: 402-406.
• Mortimer RK, Johnston JR (1959) Life span of individual yeast cells. Nature 183: 1751-1752.
• Muller I, Zimmermann M, Becker D, Flomer M (1980) Calendar life span versus budding life span of Saccharomyces cerevisiae. Mech Ageing Dev 12: 47-52.
• Munoz-Espin D, Serrano M (2014) Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Bio 15: 482-496.
• Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K (2012) Neuroprotective effects of lutein in the retina. Curr Pharm Design 18: 51-56.
• Polymenis M, Kennedy BK (2012) Chronological and replicative lifespan in yeast: Do they meet in the middle? Cell Cycle 11: 3531-3532.
• Sinclair D, Mills K, Guarente L (1998) Aging in Saccharomyces cerevisiae. Annu Rev Microbiol 52: 533-560.
• Sinclair DA, Guarente L (1997) Extrachromosomal rDNA circles - a cause of aging in yeast. Cell 91: 1033-1042.
• Smith ED, Tsuchiya M, Fox LA, Dang N, Hu D, Kerr EO, Johnston ED, Tchao BN, Pak DN, Welton KL, Promislow DE, Thomas JH, Kaeberlein M, Kennedy BK (2008) Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res 18: 564-570.
• Sohal RS, Brunk UT (1989) Lipofuscin as an indicator of oxidative stress and aging. In Lipofuscin and Ceroid Pigments, Porta EA ed, pp 17-29. City.
• Tufekci KU, Oner MG, Meuwissen RL, Genc S (2014) The Role of MicroRNAs in Human Diseases. Methods in Molecular Biology (Clifton NJ) 1107: 33-50.
• van Deursen JM (2014) The role of senescent cells in ageing. Nature 509: 439-446.
• Varghese J, Lim SF, Cohen SM (2010) Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe. Gene Dev 24: 2748-2753.
• Woldringh CL, Huls PG, Vischer NO (1993) Volume growth of daughter and parent cells during the cell-cycle of Saccharomyces cerevisiae a/alpha as determined by image cytometry. J Bacteriol 175: 3174-3181.
• Wright J, Dungrawala H, Bright RK, Schneider BL (2013) A growing role for hypertrophy in senescence. FEMS Yeast Res 13: 2-6.
• Yang J, Dungrawala H, Hua H, Manukyan A, Abraham L, Lane W, Mead H, Wright J, Schneider BL (2011) Cell size and growth rate are major determinants of replicative lifespan. Cell Cycle 10: 144-155.
• Zadrag-Tecza R, Kwolek-Mirek M, Bartosz G, Bilinski T (2009) Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae. Biogerontology 10: 481-488.
• Zadrag-Tecza R, Molon M, Mamczur J, Bilinski T (2013) Dependence of the yeast Saccharomyces cerevisiae post-reproductive lifespan on the reproductive potential. Acta Biochim Pol 60: 111-115.
• Zadrag R, Bartosz G, Bilinski T (2008) Is the yeast a relevant model for aging of multicellular organisms? An insight from the total lifespan of Saccharomyces cerevisiae. Curr Aging Sci 1: 159-65.