Preferences help
enabled [disable] Abstract
Number of results
2014 | 61 | 1 | 63-65
Article title

mRNA Regulatory elements and bacterial virulence

Title variants
Languages of publication
Pathogenic bacteria cause many diseases, some of which are fatal. For researchers, it is a challenge to understand bacterial mechanisms of pathogenicity, including their virulence pathways regulated by RNA. This work presents data on the mechanisms of regulation and expression of several virulence factors coded by RNA, namely 5' UTR fragments, riboswitches and small non-coding RNA (sRNA).
RNA   5'UTR   riboswitches   sRNA  
Physical description
  • Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland
  • Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland
  • Altuvia S, Kornitzer D, Teff D, Oppenheim AB (1989) Alternative mRNA structures of the cIII gene of bacteriophage λ determine the rate of its translational initiation. J Mol Biol 210: 265-280.
  • Chambers JR, Sauer K (2013) Small RNAs and their role in biofilm formation. Trends in Microbiology 21: 39-49.
  • Coppins RL, Hall KB, Groisman EA (2007) The intricate world of riboswitches. Curr Opin Microbiol 10: 176-181.
  • Falconi M, Colonna B, Prosseda G, Micheli G, Gualerzi CO (1998) Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature-dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H-NS. EMBO J 17: 7033-7043.
  • Fällman M, Gustavsson A (2005) Cellular mechanisms of bacterial internalization counteracted by Yersinia. Int Rev Cytol 246: 135-188.
  • Freitag NE, Port GC, Miner MD (2009) Listeria monocytogenes - from saprophyte to intracellular pathogen. Nature Rev Microbiol 7: 623-628.
  • de la Fuente M, Valera S, Martinez-Guitarte JL (2012) ncRNAs and thermoregulation: A view in prokaryotes and eukaryotes. FEBS Letters 586: 4061-4069
  • Gottesman S (2004) The small RNA regulators of Escherichia coli: roles and mechanisms. Annu Rev Microbiol 58: 303-328.
  • Grieshaber NA, Grieshaber SS, Fischer ER, Hackstadt T (2006) A small RNA inhibits translation of the histone-like protein Hc1 in Chlamydia trachomatis. Mol Microbiol 59: 541-550.
  • Gripenland J, Netterling S, Loh E, Tiensuu T, Toledo-Arana A, Johansson J (2010) RNAs: regulators of bacterial virulence. Nature Rev Microbiol 8: 857-866.
  • Heurlier K, Williams F, Heeb S, Dormond C, Pessi G, Singer D, Camara M, Williams P, Haas D (2004) Positive control of swarming, rhamnopolipid synthesis, and lipase production by the posttranscriptional RsmA/RsmZ system in Pseudomonas aeuroginosa PAO1. J Bacteriol 186: 2936-2945.
  • Huntzinger E, Boisset S, Saveanu C, Benito Y, Geissmann T, Namane A, Lina G, Etienne J, Ehresmann B, Ehresmann C, Jacquier A, Vandenesch F, Romby P (2005) Staphylococcus aureus RNAIII and the endoribonucelase III coordinately regulate spa gene expression. EMBO J 24: 824-835.
  • Hurme R, Berndt KD, Normark SJ, Rhen M (1997) A proteinaceous gene regulatory thermometer in Salmonella. Cell 90: 55-64.
  • Hurme R, Rhen M (1998) Temperature sensing in bacterial gene regulation - what it all boils down to. Mol Microbiol 30: 1-6.
  • Jaworski A, Dobrowolska A, Stączek P (2005) RNA may control expression of several genes and metabolic pathways in bacterial cells. Post Mikrobiol 22: 89-98.
  • Johansson J, Mandin P, Renzoni A, Chiaruttini C, Springer M, Cossart P (2002) An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes. Cell 110: 551-561.
  • Kirn TJ, Jude BA, Taylor RK (2005) A colonization factor links Vibrio cholerae environmental survival and human infection. Nature 438: 863-866.
  • Kulkarni RV, Kulkarni PR (2007) Computational approaches for the discovery of bacterial small RNAs. Methods 43: 131-139.
  • Li W, Ying X, Lu Q, Chen L (2012) Predicting sRNAs and their targets in bacteria. Genomics Proteomics Bioinformatics 10: 276-284.
  • Liu Y, Cui Y, Mukherjee A, Chatterjee AK (1998) Characterization of a novel RNA regulator of Erwinia carotovora ssp. carotovora that controls production of extracellular enzymes and secondary metabolites. Mol Microbiol 29: 219-234.
  • Loh E, Gripenland J, Johansson J (2006) Control of Listeria monocytogenes virulence by 5'-untranslated RNA. Trends Microbiol 14: 294-298.
  • Mandal M, Boese B, Barrick JE, Winkler WC, Breaker RR (2003) Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria. Cell 113: 577-586.
  • Miller MB, Skorupski K, Lenz DH, Taylor RK, Bassler BL (2002) Parallel quorum sensing systems converge to regulate virulence in Vibrio cholera. Cell 110: 303-314.
  • Morita MT, Tanaka Y, Kodama TS, Kyogoku Y, Yanagi H, Yura T (1999) Translational induction of heat shock transcription factor σ32: evidence for a built-in RNA thermosensor. Genes Dev 13: 655-665.
  • Nechooshtan G, Elgrably-Weiss M, Sheaffer A, Westhof E, Altuvia S (2009) A pH-responsive riboregulator. Genes Dev 23: 2650-2662.
  • Nocker A, Hausherr T, Balsiger S, Krstulovic NP, Hennecke H, Narberhaus F (2001) A mRNA-based thermosensor controls expression of rhizobial heat shock genes. Nucleic Acids Res 29: 4800-4807.
  • Novick RP (2006) Staphylococcal pathogenesis and pathogenicity factors: genetics and regulation. In Gram positive pathogens, 2 edn. Fischetti A, Novick RP, Feretti J, Portnoy D, Rood J, eds, pp 496-516. ASM Press, Washington, D.C.
  • Nudler E, Mironov AS (2004) The riboswitch control of bacterial metabolism. Trends Biochem Sci 29: 11-17.
  • Ramos CG, Grilo AM, da Costa PJ, Leităo JH (2013) Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia J2315. Genomics 101: 139-148.
  • Repoila F, Majdalani N, Gottesman S (2003) Small non-coding RNAs, co-ordinators of adaptation processes in Escherichia coli: the RpoS paradigm. Mol Microbiol 48: 855-861.
  • Servant P, Mazodier P (1996) Heat induction of hsp18 gene expression in Streptomyces albus G: transcriptional and posttranscriptional regulation. J Bacteriol 178: 7031-7036.
  • Sonnleitner E., Gonzalez N, Sorger-Domenigg T, Heeb S, Richter AS, Backofen R, Williams P, Hüttenhofer A, Haas D, Bläsi U (2011) The small RNA PhrS stimulates synthesis of the Pseudomonas aeruginosa quinolone signal. Mol Microbiol 80: 868-885
  • Storz G, Altuvia S, Wassarman KM (2005) An abundance of RNA regulators. Annu Rev Biochem 74: 199-217.
  • Sudarsan N, Lee ER, Weinberg Z, Moy RH, Kim JN, Link KH, Breaker RR (2008) Riboswitches in Eubacteria sense the second messenger cyclic Di-GMP. Science 321: 411-413.
  • Wassarman KM (2002) Small RNAs in bacteria: diverse regulators of gene expression in response to environmental changes. Cell 109: 141-144.
  • Winkler WC, Breaker RR (2005) Regulation of bacterial gene expression by riboswitches. Annu Rev Microbiol 59: 487-517.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.