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2014 | 61 | 4 | 639-649
Article title

Cyclooxygenase pathways

Content
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EN
Abstracts
EN
This review compiles the current knowledge on the effects of prostanoids - arachidonic acid metabolites - on their own synthesis, activity and degradation. Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between a thromboxane A2 and prostaglandin I2 receptors. The questions of desensitization and internalization of receptors are discussed. The stages of the inflammatory response and tumor progression are analyzed against the background of the disruption of the synthesis of prostanoids. Special attention is given to the significance of 15-deoxy-Δ12,14-prostaglandin J2 in the regulation of the synthesis of prostanoids and its role as an anti-inflammatory agent. Ultimately, therapeutic approaches as used in various treatments are discussed in the light of the available knowledge.
Year
Volume
61
Issue
4
Pages
639-649
Physical description
Dates
published
2014
received
2013-11-20
revised
2014-06-16
accepted
2014-09-06
(unknown)
2014-10-23
Contributors
author
  • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
  • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
  • Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin, Poland
  • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
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bwmeta1.element.bwnjournal-article-abpv61p639kz
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