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2014 | 61 | 3 | 531-539
Article title

Virus-like particles as vaccine

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EN
Abstracts
EN
This review presents data on commercial and experimental virus-like particle (VLP) vaccines, including description of VLP vaccines against influenza. Virus-like particles are multimeric, sometimes multiprotein nanostructures assembled from viral structural proteins and are devoid of any genetic material. VLPs present repetitive high-density displays of viral surface proteins. Importantly, they contain functional viral proteins responsible for cell penetration by the virus, ensuring efficient cell entry and thus tissue-specific targeting, determined by the origin of the virus. The foremost application of VLPs is in vaccinology, where they provide delivery systems that combine good safety profiles with strong immunogenicity and constitute a safe alternative to inactivated infectious viruses. These stable and versatile nanoparticles display excellent adjuvant properties capable of inducing innate and cognate immune responses. They present both, high-density B-cell epitopes, for antibody production and intracellular T- cell epitopes, thus inducing, respectively, potent humoral and cellular immune responses. Uptake of VLPs by antigen-presenting cells leads to efficient immune responses resulting in control of pathogenic microorganisms.
Publisher

Year
Volume
61
Issue
3
Pages
531-539
Physical description
Dates
published
2014
received
2014-07-17
revised
2014-08-20
accepted
2014-09-04
(unknown)
2014-09-18
Contributors
  • Therex, TIMC-IMAG, CNRS UMR 5525, UJF, La Tronche, France
author
  • Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
author
  • Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv61p531kz
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