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2014 | 61 | 3 | 485-487
Article title

A clinical utility of a strip test for influenza A/B and comparison with detection by RT PCR

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EN
Abstracts
EN
Introduction and objective: In June 2009 the World Health Organization announced influenza pandemic caused by A/H1N1/v virus. It became crucial to recognize new cases of A/H1N1/v infection. An effective screening diagnostic procedure was needed for patients suffering from influenza-like symptoms for making an initial diagnosis and analyzing epidemiological pattern of infection. We used a strip test for influenza A/B as a screening diagnostic procedure for patients suffering from influenza-like symptoms for making an initial diagnosis. For comparison, RT PCR for detecting A/H1N1/v was performed. The aim of this study was to assess the efficacy and sensitivity of the strip test and its value for making initial diagnosis of influenza A/H1N1/v. Material and methods: Strip testing for the influenza A/B infection was performed on 1123 patients with influenza-like symptoms in the Admission Unit of the Regional Infectious Diseases Hospital in Warsaw. Strip test results were analyzed according to the age of patients and season of the year. For 97 patients strip test results for detecting A/H1N1 infection were compared with those obtained by RT PCR. Results: There were no statistically significant differences found between the methods and strip testing demonstrated sensitivity of 61% and specificity of 71%. Conclusions: No statistically significant differences were found between the two methods, however, strip test had low sensitivity and specificity.
Publisher

Year
Volume
61
Issue
3
Pages
485-487
Physical description
Dates
published
2014
received
2014-08-31
revised
2014-09-01
accepted
2014-09-07
(unknown)
2014-09-12
Contributors
author
  • Regional Infectious Diseases Hospital, Warsaw, Poland
  • Regional Infectious Diseases Hospital, Warsaw, Poland
  • Regional Infectious Diseases Hospital, Warsaw, Poland
  • Chief Sanitary Inspectorate, Warsaw, Poland
  • Regional Infectious Diseases Hospital, Warsaw, Poland
References
  • CDC (2009a) Performance of rapid influenza diagnostic tests during two school outbreaks of 2009 pandemic influenza A (H1N1) Virus Infection - Connecticut, 302: 1962-1964.
  • CDC (2009b) Interim guidance for the detection of novel influenza a virus using rapid influenza diagnostic tests. Atlanta, GA: US Department of Health and Human Services.
  • CDC (2009c) Evaluation of rapid influenza diagnostic tests for detection of novel influenza A (H1N1) virus - United States, 2009. Morb Mortal Wkly Rep 58: 826-829.
  • Cholewińska G, Higersberger J, Podlasin R, Wiercińska-Drapało A, Lipowski D, Olszyńska-Krowicka M et al. (2010a) Influence of concomitant illness on clinical manifestations and severity of A/H1N1 influenza infection among patients hospitalized in the Hospital of Infectious Diseases in Warsaw - clinical cases. Przegl Epidemiol 64: 21-25 (in Polish).
  • Cholewińska G, Higersberger J, Podlasin R, Wiercińska-Drapało A, Lipowski D, Olszyńska-Krowicka M et al. (2010b) Clinical manifestations, diagnosis and treatment of swine flu (A/H1N1) infection among patients hospitalized in the Hospital of Infectious Diseases in Warsaw in 2009. Przegl Epidemiol 64: 15-19 (in Polish).
  • Dwyer DE (2011) INSIGHT Influenza Study Group. Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002 and FLU 003 studies. Vaccine 29 (Suppl 2): B56-B62.
  • Faix DJ, Sherman SS, Waterman SH (2009) Rapid-test sensitivity for novel swine-origin Influenza A (H1N1) virus in humans. N Engl J Med 361: 728-729.
  • Ginocchio CC, Zhang F, Manji R (2009) Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak. J Clin Virol 45: 191-195.
  • Uyeki TM, Prasad R, VuKotich C (2009) Low sensitivity of rapid diagnostic tests for influenza. Clin Infect Dis 48: e89-e92.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv61p485kz
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