In vivo reassortment of influenza viruses

• Authors: Kinga Urbaniak , Iwona Markowska-Daniel
• Languages of publication: EN

Abstracts

EN

The genetic material of influenza A virus consists of eight negative-sense RNA segments. Under suitable conditions, the segmented structure of the viral genome allows an exchange of the individual gene segments between different strains, causing formation of new reassorted viruses. For reassortment to occur, co-infection with two or more influenza virus strains is necessary. The reassortment is an important evolutionary mechanism which can result in antigenic shifts that modify host range, pathology, and transmission of the influenza A viruses. In this process, the influenza virus strain with epidemic and/or pandemic potential can be created. Cases of this kind were in 1957 (Asian flu), 1968 (Hong Kong flu) and recently in 2009 (Mexico). Viruses containing genes of avian, swine, and/or human origin are widespread around the world, for example the triple reassortant H1N1 virus causing the 2009 influenza pandemic in 2009 that has become a seasonal virus. The aim of the study is to present the mechanism of reassortment and the results of experimental co-infection with different influenza viruses.

Keywords

EN

influenza A viruses

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 3
• Pages: 427-431

Dates

published

2014

received

2014-05-29

revised

2014-08-18

accepted

2014-08-22

(unknown)

2014-09-03

Contributors

author

Kinga Urbaniak

• Department of Swine Diseases, National Veterinary Research Institute, Puławy, Poland

author

Iwona Markowska-Daniel

• Department of Swine Diseases, National Veterinary Research Institute, Puławy, Poland

References

• Brown IH (2000) The epidemiology and evolution of influenza viruses in pigs. Vet Microbiol 74: 29-46.
• Castrucci MR, Donatelli I, Sidoli L, Barigazzi G, Kawaoka Y, Webster RG (1993) Genetic reassortment between avian and human influenza A viruses in Italian pigs. Virology 193: 503-506.
• Chen LM, Davis CT, Zhou H, Cox NJ, Donis RO (2008) Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses. PLoS Pathog 4: e1000072.
• Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O'Neill R, Schickli J, Palese P, Henklein P, Bennink JR, Yewdell JW (2001) A novel influenza A virus mitochondrial protein that induces cell death. Nat Med 7: 1306-1312.
• Cong YL, Pu J, Liu QF, Wang S, Zhang GZ, Zhang XL, Fan WX, Brown EG, Liu JH (2007) Antigenic and genetic characterization of H9N2 swine influenza viruses in China. J Gen Virol 88: 2035-2041.
• de Vries E, Tscherne DM, Wienholts MJ, Cobos-Jiménez V, Scholte F, García-Sastre A, Rottier PJ, de Haan CA (2011) Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway. PLoS Pathog 7: e1001329.
• Ducatez MF, Hause B, Stigger-Rosser E, Darnell D, Corzo C, Juleen K, Simonson R, Brockwell-Staats C, Rubrum A, Wang D, Webb A, Crumpton JC, Lowe J, Gramer M, Webby RJ (2011) Multiple Reassortment between Pandemic (H1N1) 2009 and Endemic Influenza Viruses in Pigs, United States. Emerg Infect Dis 17: 1624-1629.
• Gerber M, Isel C, Moules V, Marquet R (2014) Selective packaging of the influenza A genome and consequences for genetic reassortment. Trends Microbiol 'in press'.
• Goto H, Kawaoka Y (2001) Influenzavirus A. In The Springer Index of Viruses. Tidona CA, Darai G, eds, pp 602-606. Springer
• Julkunen I, Sareneva T, Pirhonen J, Ronni T, Melén K, Matikainen S (2001) Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine Growth Factor Rev 12: 171-180.
• Kowalczyk A, Markowska-Daniel I (2010) Phylogenetic analysis of swine influenza viruses isolated in Poland. Pol J Vet Sci 13: 37-44.
• Kowalczyk A, Urbaniak K, Markowska-Daniel I (2012) Phylogenetic analysis of the first Polish H1N2 swine influenza virus isolate. Bull Vet Inst Pulawy 56: 419-424.
• Lakadamyali M, Rust MJ, Zhuang X (2004) Endocytosis of influenza viruses. Microbes Infect 6: 929-936.
• Li C, Hatta M, Nidom CA, Muramoto Y, Watanabe S, Neumann G, Kawaoka Y (2010) Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence. Proc Natl Acad Sci USA 107: 4687-4692.
• Lu L, Lycett SJ, Leigh Brown AJ (2014) Reassortment patterns of avian influenza virus internal segments among different subtypes. BMC Evol Biol 14: 16.
• Ma W, Vincent AL, Gramer MR, Brockwell CB, Lager KM, Janke BH, Gauger PC, Patnayak DP, Webby RJ, Richt JA (2007) Identification of H2N3 influenza A viruses from swine in the United States. Proc Natl Acad Sci USA 104: 20949-20954.
• Ma W, Vincent AL, Lager KM, Janke BH, Henry SC, Rowland RR, Hesse RA, Richt JA (2010) Identification and characterization of a highly virulent triple reassortant H1N1 swine influenza virus in the United States. Virus Genes 40: 28-36.
• Markowska-Daniel I, Urbaniak K, Porowski M, Karbowiak P, Kowalczyk A, Kozak E, Pejsak Z (2013) Emergence of the pandemic H1N1 2009 influenza A virus in swine herds in Poland. Bull Vet Inst Pulawy 57: 293-300.
• Moreno A, Di Trani L, Faccini S, Vaccari G, Nigrelli D, Boniotti MB, Falcone E, Boni A, Chiapponi C, Sozzi E, Cordioli P (2011) Novel H1N2 swine influenza reassortant strain in pigs derived from the pandemic H1N1/2009 virus. Vet Microbiol 149: 472-477.
• Neumann G, Brownlee GG, Fodor E, Kawaoka Y (2004) Orthomyxovirus replication, transcription, and polyadenylation. Curr Top Microbiol Immunol 283: 121-43.
• Neumann G, Noda T, Kawaoka Y (2009) Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 459: 931-939.
• Octaviani CP, Ozawa M, Yamada S, Goto H, Kawaoka Y (2010) High level of genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses. J Virol 84: 10918-10922.
• Palese P, Shaw ML (2007) Orthomyxoviridae: the viruses and their replication. In Fields Virology, 5th edn. Knipe DM, Howley PM, eds, pp 1647-1689. Lippincott Williams & Wilkins, Philadelphia.
• Poonsuk S, Sangthong P, Petcharat N, Lekcharoensuk P (2013) Genesis and genetic constellations of swine influenza viruses in Thailand. Vet Microbiol 167: 314-326.
• Reperant LA, Kuiken T, Osterhaus AD (2012) Adaptive pathways of zoonotic influenza viruses: from exposure to establishment in humans. Vaccine 30: 4419-4434.
• Resa-Infante P, Jorba N, Coloma R, Ortin J (2011) The influenza virus RNA synthesis machine: advances in its structure and function. RNA Biol 8: 207-215.
• Shin JY, Song MS, Lee EH, Lee YM, Kim SY, Kim HK, Choi JK, Kim CJ, Webby RJ, Choi YK (2006) Isolation and characterization of novel H3N1 swine influenza viruses from pigs with respiratory diseases in Korea. J Clin Microbiol 44: 3923-3927.
• Sieczkarski SB, Whittaker GR (2002) Influenza virus can enter and infect cells in the absence of clathrin-mediated endocytosis. J Virol 76: 10455-10464.
• Starick E, Lange E, Fereidouni S, Bunzenthal C, Hoveler R, Kuczka A, grosse Beilage E, Hamann HP, Klingelhöfer I, Steinhauer D, Vahlenkamp T, Beer M, Harder T (2011) Reassorted pandemic (H1N1) 2009 influenza A virus discovered from pigs in Germany. J Gen Virol 92: 1184-1188.
• Sun Y, Qin K, Wang J, Pu J, Tang Q, Hu Y, Bi Y, Zhao X, Yang H, Shu Y, Liu J (2011) High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses. Proc Natl Acad Sci U S A 108: 4164-4169.
• Tarus B, Chevalier C, Richard CA, Delmas B, Di Primo C, Slama-Schwok A (2012) Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding. PLoS One 7: e30038.
• Taubenberger JK, Kash JC (2010) Influenza virus evolution, host adaptation, and pandemic formation. Cell Host Microbe 7: 440-451.
• Tremblay D, Allard V, Doyon JF, Bellehumeur C, Spearman JG, Harel J, Gagnon CA (2011) Emergence of a new swine H3N2 and pandemic (H1N1) 2009 influenza A virus reassortant in two Canadian animal populations, mink and swine. J Clin Microbiol 49: 4386-4390.
• Tscherne DM, García-Sastre A (2011) Virulence determinants of pandemic influenza viruses. J Clin Invest 121: 6-13.
• Vijaykrishna D, Poon LL, Zhu HC, Ma SK, Li OT, Cheung CL, Smith GJ, Peiris JS, Guan Y (2010) Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science 328: 1529.
• Vijaykrishna D, Smith GJ, Pybus OG, Zhu H, Bhatt S, Poon LL, Riley S, Bahl J, Ma SK, Cheung CL, Perera RA, Chen H, Shortridge KF, Webby RJ, Webster RG, Guan Y, Peiris JS (2011) Long-term evolution and transmission dynamics of swine influenza A virus. Nature 473: 519-522.
• Zell R, Scholtissek C, Ludwig S (2013) Genetics, evolution, and the zoonotic capacity of European Swine influenza viruses. Curr Top Microbiol Immunol 370: 29-55.
• Zhang Y, Lin X, Wang G, Zhou J, Lu J, Zhao H, Zhang F, Wu J, Xu C, Du N, Li Z, Zhang Y, Wang X, Bi S, Shu Y, Zhou H, Tan W, Wu X, Chen Z, Wang Y (2010) Neuraminidase and hemagglutinin matching patterns of a highly pathogenic avian and two pandemic H1N1 influenza A viruses. PLoS ONE 5: e9167.