Role of the host genetic variability in the influenza A virus susceptibility

• Authors: Ana Arcanjo , Giovanni Mazzocco , Silviene de Oliveira , Dariusz Plewczynski , Jan Radomski
• Languages of publication: EN

Abstracts

EN

The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.

Keywords

EN

Influenza A virus; host-pathogen interactions

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 3
• Pages: 403-419

Dates

published

2014

received

2014-05-21

revised

2014-08-13

accepted

2014-08-28

(unknown)

2014-09-04

Contributors

author

Ana Arcanjo

• Laboratório de Genética, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brazil

author

Giovanni Mazzocco

• Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland

author

Silviene de Oliveira

• Laboratório de Genética, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brazil

author

Dariusz Plewczynski

• Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland

author

Jan Radomski

• Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland

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