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2014 | 61 | 3 | 403-419
Article title

Role of the host genetic variability in the influenza A virus susceptibility

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EN
Abstracts
EN
The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.
Publisher

Year
Volume
61
Issue
3
Pages
403-419
Physical description
Dates
published
2014
received
2014-05-21
revised
2014-08-13
accepted
2014-08-28
(unknown)
2014-09-04
Contributors
author
  • Laboratório de Genética, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brazil
  • Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland
  • Laboratório de Genética, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brazil
  • Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland
author
  • Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland
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