The relation of PON1-L55M gene polymorphism and clinical manifestation of Behcet's disease

• Authors: Ahmet Dursun , Salih Cicek , Fatih Keni , Sevim Karakas-Celik , Tuna Sezer , Cevdet Altinyazar
• Languages of publication: EN

Abstracts

EN

Purpose: Behçet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Paraoxonase is believed to play an important role in protection of LDL and HDL particles from oxidation, in antioxidant effect against lipid peroxidation on cellular membranes, and in anti-inflammatory process. Lipid peroxidation and free oxygen radicals have been thought to play a role in pathogenesis of BD. The association of paraoxonase gene polymorphisms with Behçet's Disease in a group of Turkish patients with clinical manifestations and healthy controls has been investigated. Patients and Methods: Paraoxonase (PON-1-L55M) gene polymorphism was investigated in 50 Behcet patients and 50 healthy individuals with a PCR/RFLP method. Results: There were significant differences between patients and the control group in allele frequencies of the PON1 L55M polymorphism (p=0.04). Also, when patients were compared with the control group according to clinical manifestations, this statistical significance was getting sharper. Compared with the PON55 L allele, the M allele was associated with greater than 3.5 fold (OR 3.5, 95% CI 1.3-8.9) increased risk of ocular (OR 2.4, 95% CI 1.1-5.3), 2.4 fold joint and 3.1 fold (OR 3.1, 95% CI 1.1-8.4) central nervous system manifestations of BD. Conclusion The PON L55M gene polymorphism seemed to play a role in the pathogenesis of BD.

Keywords

EN

PON1 gene; Polymorphism; Behçet's disease

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 2
• Pages: 271-274

Dates

published

2014

received

2013-06-25

revised

2014-04-02

accepted

2014-04-10

(unknown)

2014-06-16

Contributors

author

Ahmet Dursun

• Bulent Ecevit University, Medical Faculty, Medical Genetics Dept., Zonguldak, Turkey

author

Salih Cicek

• Bulent Ecevit University, Medical Faculty, Medical Genetics Dept., Zonguldak, Turkey

author

Fatih Keni

• Istanbul Training and Research Hospital, Medical Genetics Department, Istanbul, Turkey

author

Sevim Karakas-Celik

• Bulent Ecevit University, Medical Faculty, Medical Genetics Dept., Zonguldak, Turkey

author

Tuna Sezer

• Bulent Ecevit University, Medical Faculty, Dermatology Department, Zonguldak, Turkey

author

Cevdet Altinyazar

• Selcuk University, Selcuklu Medical Faculty, Dermatology Department, Konya, Turkey

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