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2014 | 61 | 2 | 271-274
Article title

The relation of PON1-L55M gene polymorphism and clinical manifestation of Behcet's disease

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EN
Abstracts
EN
Purpose: Behçet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Paraoxonase is believed to play an important role in protection of LDL and HDL particles from oxidation, in antioxidant effect against lipid peroxidation on cellular membranes, and in anti-inflammatory process. Lipid peroxidation and free oxygen radicals have been thought to play a role in pathogenesis of BD. The association of paraoxonase gene polymorphisms with Behçet's Disease in a group of Turkish patients with clinical manifestations and healthy controls has been investigated. Patients and Methods: Paraoxonase (PON-1-L55M) gene polymorphism was investigated in 50 Behcet patients and 50 healthy individuals with a PCR/RFLP method. Results: There were significant differences between patients and the control group in allele frequencies of the PON1 L55M polymorphism (p=0.04). Also, when patients were compared with the control group according to clinical manifestations, this statistical significance was getting sharper. Compared with the PON55 L allele, the M allele was associated with greater than 3.5 fold (OR 3.5, 95% CI 1.3-8.9) increased risk of ocular (OR 2.4, 95% CI 1.1-5.3), 2.4 fold joint and 3.1 fold (OR 3.1, 95% CI 1.1-8.4) central nervous system manifestations of BD. Conclusion The PON L55M gene polymorphism seemed to play a role in the pathogenesis of BD.
Publisher

Year
Volume
61
Issue
2
Pages
271-274
Physical description
Dates
published
2014
received
2013-06-25
revised
2014-04-02
accepted
2014-04-10
(unknown)
2014-06-16
Contributors
author
  • Bulent Ecevit University, Medical Faculty, Medical Genetics Dept., Zonguldak, Turkey
author
  • Bulent Ecevit University, Medical Faculty, Medical Genetics Dept., Zonguldak, Turkey
author
  • Istanbul Training and Research Hospital, Medical Genetics Department, Istanbul, Turkey
  • Bulent Ecevit University, Medical Faculty, Medical Genetics Dept., Zonguldak, Turkey
author
  • Bulent Ecevit University, Medical Faculty, Dermatology Department, Zonguldak, Turkey
  • Selcuk University, Selcuklu Medical Faculty, Dermatology Department, Konya, Turkey
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv61p271kz
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