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2014 | 61 | 2 | 205-210
Article title

Biocatalytic synthesis of δ-gluconolactone and ε-caprolactone copolymers

Content
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EN
Abstracts
EN
The biodegradability and biocompatibility properties of ε-caprolactone homopolymers place it as a valuable raw material, particularly for controlled drug delivery and tissue engineering applications. However, the usefulness of such materials is limited by their low hydrophilicity and slow biodegradation rate. In order to improve polycaprolactone properties and functionalities, copolymerization of ε-caprolactone with δ-gluconolactone was investigated. Since enzymatic reactions involving sugars are usually hindered by the low solubility of these compounds in common organic solvents, finding the best reaction medium was a major objective of this research. The optimal copolymerization conditions were set up by using different organic media (solvent and solvents mixtures), as well as solvent free systems that are able to dissolve (completely or partially) sugars, and are nontoxic for enzymes. Native and immobilized lipases by different immobilization techniques from Candida antarctica B and Thermomyces lanuginosus have been used as biocatalyst at 80°C. Although the main copolymer amount was synthesized in DMSO:t-BuOH (20:80) medium, the highest polymerization degrees, up to 16 for the copolymer product, were achieved in solventless conditions. The products, cyclic and linear polyesters, have been characterized by FT-IR and MALDI-TOF MS analysis. The reaction product analysis revealed the formation of cyclic products that could be the major impediment of further increase of the chain length.
Year
Volume
61
Issue
2
Pages
205-210
Physical description
Dates
published
2014
received
2013-10-25
revised
2014-04-15
accepted
2014-04-22
(unknown)
2014-06-06
Contributors
  • Faculty of Industrial Chemistry and Environmental Engineering, University "Politehnica" of Timisoara, Timisoara, Romania
  • Faculty of Industrial Chemistry and Environmental Engineering, University "Politehnica" of Timisoara, Timisoara, Romania
author
  • Department of Applied Chemistry, University of Debrecen, Debrecen, Hungary
author
author
  • Wageningen UR Food & Biobased Research, Wageningen, The Netherlands
  • Faculty of Industrial Chemistry and Environmental Engineering, University "Politehnica" of Timisoara, Timisoara, Romania
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv61p205kz
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