Frequencies of HLA-DQ2 and HLA-DQ8 haplotypes in Czech and Slovak coeliac patients and the healthy population

• Authors: Katerina Wroblova , Michal Kolorz , Igor Pav , Zuzana Horakova , Petra Filipova , Milan Bartos , Ladislava Bartosova
• Languages of publication: EN

Abstracts

EN

Coeliac disease is an autoimmune disorder with genetic predisposition. The aim was to determine the frequency of HLA-DQ2 and HLA-DQ8 in Czech and Slovak patients and the healthy population. The study included 127 patients and 66 healthy volunteers. HLA-DQ2 was identified in 85.03% patients, and 24.24% healthy individuals (P=0.0001; OR17.7632; CI=8.4347-37.4088). HLA-DQ8 was identified in 11.81% patients and 15.5% healthy individuals. HLA-DQ8 occurred more often in HLA-DQ2-negative patients compared to HLA-DQ2-positive patients (P=0.0494; OR3.5; CI 1.0428-11.7468). At least one of the studied HLA-variants was found more often in patients than in healthy individuals (P=0.0001; OR58.8; CI 7.6856-449.8602).

Keywords

EN

coeliac disease; HLA haplotype; HLA-DQ2; HLA-DQ8; Czech and Slovak population

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 1
• Pages: 191-193

Dates

published

2014

received

2013-11-07

revised

2014-03-06

accepted

2014-03-07

(unknown)

2014-03-22

Contributors

author

Katerina Wroblova

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

author

Michal Kolorz

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

author

Igor Pav

• Gastroenterological Clinic SMU and University Hospital in Bratislava-Petrzalka, Bratislava, Slovak Republic

author

Zuzana Horakova

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

author

Petra Filipova

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

author

Milan Bartos

• Department of Natural Drugs, UVPS Brno, Brno, Czech Republic

author

Ladislava Bartosova

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

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