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2014 | 61 | 1 | 179-184
Article title

Thermodynamic aspects of the self-assembly of DsrA, a small noncoding RNA from Escherichia coli

Content
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EN
Abstracts
EN
DsrA is an Escherichia coli small noncoding RNA that acts by base pairing to some mRNAs in order to control their translation and turnover. It was recently shown that DsrA is able to self-associate in a way similar to DNA and to build nanostructures. Although functional consequence of this RNA self-assembly in vivo is not yet understood, the formation of such an assemblage more than likely influences the noncoding RNA function. We report here for the first time the thermodynamic basis of this natural RNA self-assembly. In particular we show that assembling of the ribonucleic acid is enthalpy driven and that the versatility of the RNA molecule is important for the polymerisation; indeed, an equivalent DNA sequence is unable to make a nanoassembly. The origin of the difference is discussed herein.
Publisher

Year
Volume
61
Issue
1
Pages
179-184
Physical description
Dates
published
2014
received
2013-12-30
revised
2014-01-18
accepted
2014-01-20
(unknown)
2014-01-22
Contributors
  • UFR SMBH, Université Paris 13, Sorbonne Paris Cité, 93017 Bobigny, France
author
  • Laboratoire Léon Brillouin, Commissariat à l'Energie Atomique, CNRS-UMR 12, CEA-Saclay, Gif-sur-Yvette Cedex, 91191 France
  • Laboratoire Léon Brillouin, Commissariat à l'Energie Atomique, CNRS-UMR 12, CEA-Saclay, Gif-sur-Yvette Cedex, 91191 France
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv61p179kz
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