Preferences help
enabled [disable] Abstract
Number of results
2014 | 61 | 1 | 129-132
Article title

The amide of galacturonic acid with lysine as an immunodominant component of the lipopolysaccharide core region from Proteus penneri 42 strain

Title variants
Languages of publication
Most Proteus lipopolysaccharides (LPSs) contain uronic acids or their amides with different amino acids, which together with other negatively charged components account for the acidic character of such LPS molecules. Previous studies have shown the significance of an amide of galacturonic acid with lysine [D-GalA(L-Lys)] for serological specificity of O-antigens from few P. mirabilis strains. In this work, the immunodominant role of GalALys was indicated for the P. penneri 42 LPS core region. The studies also showed the serological identity of core oligosaccharides from P. penneri 42 (O71), P. mirabilis 51/57 (O28) and R14/S1959 strains.
Physical description
  • Bartodziejska B, Radziejewska-Lebrecht J, Lipinska M, Knirel YA, Kononov LO, Chernyak AY, Mayer H, Rozalski A (1996) Structural and immunochemical studies on the lipopolysaccharide of the 'T-antigen'-containing mutant Proteus mirabilis R14/1959. FEMS Immunol Med Microbiol 13: 113-121.
  • Jennings HJ, Ługowski C (1981) Immunochemistry of groups A, B, and C meningococcal polysaccharide-tetanus toxoid conjugates. J Immunol 127: 1011-1018.
  • Knirel YA, Perepelov AV, Kondakova AN, Senchenkova SN, Sidorczyk Z, Rozalski A, Kaca W (2011) Structure and serology of O-antigens as the basis for classification of Proteus strains. Innate Immunity 17: 70-96.
  • Palusiak A, Dzieciątkowska M, Sidorczyk Z (2008) Application of two different kinds of sera against the Proteus penneri lipopolysaccharide core region in search of epitopes determining cross-reactions with antibodies. Arch Immunol Ther Exp 56: 135-140.
  • Palusiak A, Sidorczyk Z (2010) Characterization of epitope specificity of Proteus penneri 7 lipopolysaccharide core region. Acta Biochim Polon 57: 529-532.
  • Radziejewska-Lebrecht J, Shashkov AS, Vinogradov EV, Grosskurth H, Bartodziejska B, Rozalski A, Kaca W, Kononov LO, Chernyak AY, Mayer H, Knirel YA, Kochetkov NK (1995) Structure and epitope characterisation of the O-specific polysaccharide of Proteus mirabilis O28 containing amides of d-galacturonic acid with l-serine and l-lysine. Eur J Biochem 230: 705-712.
  • Różalski A, Torzewska A, Moryl M, Kwil I, Maszewska A, Ostrowska K, Drzewiecka D, Zabłotni A, Palusiak A, Siwińska M, Stączek P (2012) Proteus sp. - an opportunistic bacterial pathogen - classification, swarming growth, clinical significance and virulence factors. Folia Biologica et Oecologica 8: 1-17.
  • Sidorczyk Z, Zych K, Toukach FV, Arbatsky NP, Zabłotni A, Shashkov AS, Knirel YA (2002) Structure of the O-polysaccharide and classification of Proteus mirabilis strain G1 in Proteus serogroup O3. Eur J Biochem 269: 1406-1412.
  • Torzewska A, Stączek P, Różalski A (2003) Crystallization of urine mineral components may depend on the chemical nature of Proteus endotoxin polysaccharides. J Med Microbiol 52: 471-477.
  • Vinogradov E (2011) Structure of the core part of the lipopolysaccharide from Proteus mirabilis genomic strain HI4320. Biochemistry (Moscow) 76: 803-807.
  • Vinogradov EV, Sidorczyk Z, Knirel YA (2002) Structure of the lipopolysaccharide core region of the bacteria of the genus Proteus. Aust J Chem 55: 61-67.
  • Westphal O, Jann K (1965) Bacterial lipopolysaccharides. Extraction with phenol-water and further applications of the procedure. Methods Carbohydr Chem 5: 83-91.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.