Permeation of iodide from iodine-enriched yeast through porcine intestine
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Iodine deficiency is a common phenomenon, threatening the whole global human population. Recommended daily intake of iodine is 150 μg for adults and 250 μg for pregnant and breastfeeding women. About 50% of human population can be at risk of moderate iodine deficiency. Due to this fact, increased iodine supplementation is recommended, through intake of iodized mineral water and salt iodization. The aim of this study was to investigate permeation and absorption of iodide from iodine bioplex (experimental group) in comparison with potassium iodide (controls). Permeation and absorption processes were investigated in vitro using a porcine intestine. The experimental model was based on a standard Franz diffusion cell (FD-Cell). The iodine bioplex was produced using Saccharomyces cerevisiae yeast and whey powder: iodine content - 388 μg/g, total protein - 28.5%, total fat - 0.9%., glutamic acid - 41.2%, asparaginic acid - 29.4%, lysine - 24.8%; purchased from: F.Z.N.P. Biochefa, Sosnowiec, Poland. Potassium iodide was used as controls, at 388 μg iodine concentration, which was the same as in iodine-enriched yeast bioplex. A statistically significant increase in iodide permeation was observed for iodine-enriched yeast bioplex in comparison with controls - potassium iodide. After 5h the total amount of permeated iodide from iodine-enriched yeast bioplex was 85%, which is ~ 2-fold higher than controls - 37%. Iodide absorption was by contrast statistically significantly higher in controls - 7.3%, in comparison with 4.5% in experimental group with iodine-enriched yeast bioplex. Presented results show that iodide permeation process dominates over absorption in case of iodine-enriched yeast bioplex.
- Andersson M, De Benoist B, Rogers L (2010) Epidemiology of iodine deficiency: Salt iodisation and iodine status. Best Pract Res Clin Endocrinol Metab 24: 1-11.
- Dolińska B, Opaliński S, Zieliński M, Chojnacka K, Dobrzański Z, Ryszka F (2011) Iodine concentration in fodder influences the dynamics of iodine levels in hen's egg components. Biol Trace Elem Res 144: 747-752.
- Dolińska B, Zieliński M, Dobrzański Z, Chojnacka K, Opaliński S, Ryszka F. (2012) Influence of incubation conditions on hydrolysis efficiency and iodine enrichment in baker's yeast. Biol Trace Elem Res 147: 354-358.
- Dolińska B, Zieliński M, Opaliński S, Korczyński M, Dobrzański Z, Ryszka F (2010) Optimization of the conditions of iodine incorporation to Saccharomyces cerevisiae yeast. Przem Chem 90: 174-179.
- Edmonds J, Morita M (1998) The determination of iodine species in environmental and biological samples. Pure Appl Chem 70: 567-1584.
- Franz T. (1975) Percutaneous absorption on the relevance of in vitro data. J Invest Derm 64: 190-195.
- Kurosad A, Nicpoń J, Kubiak K, Jankowski M, Kungl K (2005) Iodinnutrition. Adv Clin Exp Med 14: 1019-1025.
- Melse-Boonstra A, Jaiswal N (2010) Iodine deficiency in pregnancy, infancy and childhood and its consequences for brain development. Best Pract Res Clin Endocrinol Metab 24: 29-38.
- Nicola J, Basquin C, Portulano C, Reyna-Neyra A, Paroder M, Carrasco (2009) The Na+/I- symporter mediates active iodide uptake in the intestine. Am J Physiol Cell Physiol 296: C654-C662.
- Schrauzer G (2006) Selenium yeast: Composition, quality, analysis and safety. Pure Appl Chem 78: 105-109.
- Szybiński Z (2009) Iodine prophylaxis in Poland in the light of the WHO recommendation on reduction of the daily salt intake. Pediatr Endocrino Diabetes Metab 15: 103-107.
- Szybiński Z, Jarosz M (2010) Iodine-deficiency prophylaxis and the restriction of salt consumption - a 21-st century challenge. Endokrynol Pol 61: 135-140.
- Toledo-Pereyra L, Lopez-Neblina F, Toledo A (2010) Organ freezing. Organ preservation for transplantation. 3-rd Landes Biosciences, Austin.
- World Health Organization (2008) Salt as a vehicle for fortification. Report of a WHO expert consultation. Geneva: World Health Organization: 1-27.
- Zetic V et al. (2001) Chromium uptake by Saccharomyces cerevisiae and isolation of glucose tolerance factor from yeast biomass. J Biosci 26: 217-223.
- Zimmermann M (2010) Symposium on 'Geographical and geological influence on nutrition': Iodine deficiency in industrialised countries. Proc Nutr Soc 69: 133-143.
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