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2013 | 60 | 4 | 617-621
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Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients

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Aim: Adiponectin and leptin are two adipokines playing important roles in the regulation of body weight, appetite, carbohydrate and lipid metabolism. In patients with chronic kidney disease (CKD) adipokines accumulate in serum due to reduced renal clearance. Since adipokines have pleiotropic actions, the adipokine balance may have an impact on peritoneal membrane transport. The aim of this study was to assess whether serum adiponectin and leptin levels were related to peritoneal transport and residual renal function (RRF) in newly started peritoneal dialysis patients. Methods: 25 clinically stable patients, 4 to 6 weeks after the onset of PD, were included in the study. For each patient clinical and laboratory data were reviewed and standard PET test was performed. Serum adiponectin and leptin concentrations were determined and leptin/adiponectin (L/A) ratio was calculated. Results: Serum adiponectin correlated negatively with weight, BMI and glucose concentration. Serum leptin and L/A ratio correlated positively with BMI. Serum adiponectin correlated positively with dialysate to plasma (D/P) creatinine ratio and ultrafiltration in PET test. Serum leptin level and L/A ratio correlated strongly negatively with peritoneal creatinine clearance. Conclusions: Serum adiponectin concentration is positively associated with baseline solute transport. Leptin concentration and L/A ratio are negatively associated with dialysis adequacy in newly started PD patients.
Physical description
  • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
  • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
  • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
  • Department of Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
  • Department of Human Nutrition, West Pomeranian University of Technology, Szczecin, Poland
  • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
  • Adamczak M, Szotowska M, Chudek J, Karkoszka H, Cierpka L, Więcek A (2007) Plasma adiponectin concentration in patients after successful kidney transplantation - a single-center, observational study. Clin Nephrol 67: 381-390.
  • An WS, Son YK, Kim SE Kim KH, Bae HR, Lee S, Park Y, Kim HJ, Vaziri ND (2011) Association of adiponectin and leptin with serum lipids and erythrocyte omega-3 and omega-6 fatty acids in dialysis patients. Clin Nephrol 75: 195-203.
  • Diez JJ, Iglesias P, Fernandez-Reyes MJ, Aguilera A, Bajo MA, Alvarez-Fidalgo P, Codoceo R, Selgas R (2005) Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease. Clin Endocrinol 62: 242-249.
  • Eglit T, Lember M, Ringmets I, Rajasalu T (2012) Gender differences in serum high-molecular-weight (HMW) adiponectin levels in metabolic syndrome. Eur J Endocrinol doi: 10.1530/EJE-12-0688.
  • Furuhashi M, Ura N, Higashiura K, Murakami H, Tanaka M, Moniwa N, Yoshida D, Shimamoto K (2003) Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension. Hypertension 42: 76-81.
  • Guebre-Egziabher F, Bernhard J, Funahashi T, Hadj-Aissa A, Fouque D (2005) Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. Nephrol Dial Transplant 20: 129-134.
  • Hara K, Uchida T, Takebayashi K, Sakai Y, Inoue T, Inukai T, Takayanagi K, Aso Y (2011) Determinants of serum high molecular weight (HMW) adiponectin levels in patients with coronary artery disease: associations with cardio-renal-anemia syndrome. Intern Med 50: 2953-2960.
  • Huang JW, Yen CJ, Chiang HW, Hung KY, Tsai TJ, Wu KD (2004) Adiponectin in peritoneal dialysis patients: a comparison with hemodialysis patients and subjects with normal renal function. Am J Kid Dis 43: 1047-1055.
  • Kacso IM, Lenghel A, Patiu IM, Racasan S, Orasan R, Rusu CC, Moldovan D, Bondor CI, Nita C, Hancu ND, Caprioara MG (2010) Prognostic value of plasma adiponectin in type 2 diabetic dialysis patients. Therapeutics, Pharmacology and Clinical Toxicology 14: 205-211.
  • Kim DJ, Oh DJ, Kim B, Lim YH, Kang WH, Lee BH, Lee SK, Huh W, Kim SE, Lee MK, Kang SA, Oh HY (1999) The effect of continuous ambulatory peritoneal dialysis on change in serum leptin. Perit Dial Int 19: S172-S175.
  • Kotani K, Sakane N, Saiga K, Kurozawa Y (2005) Leptin : adiponectin ratio as an atherogenic index in patients with type 2 diabetes: relationship of the index to carotid intima-media thickness. Diabetologia 48: 2684-2686.
  • Lai KN, Leung JCK (2010) Peritoneal adipocytes and their role in inflammation during peritoneal dialysis. Mediators Inflamm doi: 10.1155/2010/495416.
  • Lee CT, Ng HY, Hsu CY, Tsai YC, Yang YK, Chen TC, Chiou TT, Kuo CC, Lee WC, Hsu KT (2010) Proinflammatory cytokines, hepatocyte growth factor and adipokines in peritoneal dialysis patients. Artif Organs 34: E222-E229.
  • Lee YJ, Cho S, Kim SR (2011) The association between serum adiponectin levels and nutritional status of hemodialysis patients. Ren Fail 33: 506-511.
  • Mak RH, Cheung W, Cone RD, Marks DL (2006) Leptin and inflammation-associated cachexia in chronic kidney disease. Kidney Int 69: 794-797.
  • Momeni A, Seirafian S (2011) Relationship between serum leptin level and peritonitis in CAPD patients. Nephro-Urol Mon 3: 272-275.
  • Nanayakkara PWB, Le Poole CY, Fouque D C, van Guldener, Stehouwer CDA, Smulders YM, van Ittersum FJ, Siegert CEH, Drai J, Kostense PJ, ter Wee PM (2009) Plasma adiponectin concentration has an inverse and a non linear association with estimated glomerular filtration rate in patients with K/DOQI 3-5 chronic kidney disease. Clin Nephrol 72: 21-30.
  • Park JH, Gil HW, Yang JO, Lee EY, Hong SY (2008) Total and high molecular weight adiponectin concentrations in plasma of patients with end-stage renal disease before and after peritoneal dialysis. Nephrology 13: 181-185.
  • Park JT, Yoo TH, Kim JK, Oh HJ, Kim SJ, Yoo DE, Lee MJ, Shin DH, Han SH, Han DS, Kang SW (2013) Leptin/adiponectin ratio is an independent predictor of mortality in nondiabetic peritoneal dialysis patients. PDI 33: 67-74.
  • Ramos LF, Shintani A, Himmelfarb J, Ikizler TA (2009) Determinants of plasma adiponectin levels in nondiabetic subjects with moderate to severe chronic kidney disease. J Ren Nutr 19: 197-203.
  • Satoh N, Naruse M, Usui T, Tagami T, Suganami T, Yamada K, Kuzuya H, Shimatsu A, Ogawa Y (2004) Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients. Diabetes Care 27: 2488-2490.
  • Slee AD (2012) Exploring metabolic dysfunction in chronic kidney disease. Nutr Metab (Lond) doi: 10.1186/1743-7075-9-36.
  • Teta D, Maillard M, Halabi G, Burnier M (2008) The leptin/adiponectin ratio: Potential implications for peritoneal dialysis. Kidney Int Suppl 108: S112-S118.
  • Tsao YT, Hsu YJ, Chu NF, Lai CH, Chiu JS, Lin SH (2008) Association of plasma adiponectin and cardiovascular risk profiles in nondiabetic uremic patients on peritoneal dialysis. J Nephrol 21: 744-752.
  • Więcek A, Adamczak M, Chudek J (2007) Adiponectin - an adipokine with unique metabolic properties. Nephrol Dial Transplant 22: 981-988.
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